On the basis of the fact that several polynucleotidyl transferases, related to HIV integrase,
contain in their active site two divalent metal cations, separated by ca. 4 Å, new potential HIV …

Our prior studies showed that polyhydroxylated styrylquinolines are potent HIV-1 integrase (IN)
inhibitors that block the replication of HIV-1 in cell culture at nontoxic concentrations. To …

Self-assembly properties of HIV-1 integrase were investigated by time-resolved fluorescence
anisotropy using tryptophanyl residues as a probe. From simulation analyses, we show that …

A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and
ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an …

The relationship between Mg 2+ -dependent activity and the self-assembly state of HIV-1
integrase was investigated using different protein preparations. The first preparations, IN …

Novel variants of HIV-1 replication inhibitors of the styrylquinoline class, bearing an additional
acid group or a propenoic acid moiety at the C-5 position of the quinoline have been …

Styrylquinoline derivatives (SQ) efficiently inhibit the 3′-processing activity of integrase (IN)
with IC 50 values of between 0.5 and 5 μM. We studied the mechanism of action of these …

Self-assembly of HIV-1 integrase (IN) in solution has been studied previously by time-resolved
fluorescence, using tryptophan anisotropy decay. This approach provides information on …

We have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They
compete with the long terminal repeat substrate for integrase. Here, we describe the cellular …

We report on the efficient design and fabrication of polymeric microracetrack optical resonators
for label-free biosensing purposes. Vertically-coupled microresonators immersed in …