Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action
S Seidel, EA Singer, H Just, H Farhan, P Scholze… - Molecular …, 2005 - ASPET
Amphetamine congeners [eg, 3,4-methylenedioxymetamphetamine (MDMA), or “ecstasy”]
are substrates for monoamine transporters (ie, the transporters for serotonin, norepinephrine, …
are substrates for monoamine transporters (ie, the transporters for serotonin, norepinephrine, …
[HTML][HTML] Identification of an additional interaction domain in transmembrane domains 11 and 12 that supports oligomer formation in the human serotonin transporter
H Just, HH Sitte, JA Schmid, M Freissmuth… - Journal of Biological …, 2004 - ASBMB
Na + /Cl – -dependent neurotransmitter transporters form constitutive oligomers. The topological
arrangement is not known, but a leucine heptad repeat in transmembrane domain (TM) …
arrangement is not known, but a leucine heptad repeat in transmembrane domain (TM) …
Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled α6 and β3 …
RM Drenan, R Nashmi, P Imoukhuede, H Just… - Molecular …, 2008 - ASPET
Neuronal nicotinic acetylcholine (ACh) receptors are ligand-gated, cation-selective ion
channels. Nicotinic receptors containing α4, α6, β2, and β3 subunits are expressed in midbrain …
channels. Nicotinic receptors containing α4, α6, β2, and β3 subunits are expressed in midbrain …
[HTML][HTML] Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter
A El-Kasaby, H Just, E Malle, PC Stolt-Bergner… - Journal of biological …, 2010 - ASBMB
The serotonin transporter (SERT) is a member of the SLC6 family of solute carriers. SERT
plays a crucial role in synaptic neurotransmission by retrieving released serotonin. The …
plays a crucial role in synaptic neurotransmission by retrieving released serotonin. The …
[HTML][HTML] Functional diversity of LAP2α and LAP2β in postmitotic chromosome association is caused by an α‐specific nuclear targeting domain
S Vlcek, H Just, T Dechat, R Foisner - The EMBO Journal, 1999 - embopress.org
Lamina‐associated polypeptide 2α (LAP2α) is a non‐membrane‐bound isoform of the LAP2
family implicated in nuclear structure organization. We show that during postmitotic nuclear …
family implicated in nuclear structure organization. We show that during postmitotic nuclear …
Antibodies directed against Lewis-Y antigen inhibit signaling of Lewis-Y modified ErbB receptors
M Klinger, H Farhan, H Just, H Drobny, G Himmler… - Cancer Research, 2004 - AACR
The majority of cancer cells derived from epithelial tissue express Lewis-Y (LeY) type
difucosylated oligosaccharides on their plasma membrane. This results in the modification of cell …
difucosylated oligosaccharides on their plasma membrane. This results in the modification of cell …
Removal of the carboxy terminus of the A2A-adenosine receptor blunts constitutive activity: differential effect on cAMP accumulation and MAP kinase stimulation
M Klinger, M Kuhn, H Just, E Stefan, T Palmer… - Naunyn-Schmiedeberg's …, 2002 - Springer
The A 2A -adenosine receptor has an extended carboxy terminus (~120 amino acids), the
role of which is poorly defined. In human endothelial cells and in HEK293 cells, the A 2A -…
role of which is poorly defined. In human endothelial cells and in HEK293 cells, the A 2A -…
[HTML][HTML] The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells
O Kudlacek, H Just, VM Korkhov, N Vartian… - …, 2003 - nature.com
The adenosine A 2A receptor and the dopamine D 2 receptor are prototypically coupled to
G s and G i/G o, respectively. In striatal intermediate spiny neurons, these receptors are …
G s and G i/G o, respectively. In striatal intermediate spiny neurons, these receptors are …
Fiber type conversion alters inactivation of voltage-dependent sodium currents in murine C2C12 skeletal muscle cells
…, S Galler, J Szendroedi, H Just… - … of Physiology-Cell …, 2004 - journals.physiology.org
Each skeletal muscle of the body contains a unique composition of “fast” and “slow” muscle
fibers, each of which is specialized for certain challenges. This composition is not static, and …
fibers, each of which is specialized for certain challenges. This composition is not static, and …
Sympathoexcitation by bradykinin involves Ca2+-independent protein kinase C
T Scholze, E Moskvina, M Mayer, H Just… - Journal of …, 2002 - Soc Neuroscience
Bradykinin has long been known to excite sympathetic neurons via B 2 receptors, and this
action is believed to be mediated by an inhibition of M-currents via phospholipase C and …
action is believed to be mediated by an inhibition of M-currents via phospholipase C and …