Pseudophosphatases and pseudokinases are increasingly viewed as integral elements of
signaling pathways, and there is mounting evidence that they have frequently retained the …

For growth, survival, communication and homeostasis, cells transport a large number of
proteins to the plasma membrane and the extracellular medium by using the secretory pathway. …

The Rho family of small GTPases orchestrates fundamental biological processes such as
cell cycle progression, cell migration, and actin cytoskeleton dynamics, and their aberrant …

Selective autophagy can be mediated via receptor molecules that link specific cargoes to
the autophagosomal membranes decorated by ubiquitin-like microtubule-associated protein …

Pathogen access to host nutrients in infected tissues is fundamental for pathogen growth and
virulence, disease progression, and infection control. However, our understanding of this …

To what extent the secretory pathway is regulated by cellular signaling is unknown. In this
study, we used RNA interference to explore the function of human kinases and phosphatases …

The biogenesis of endoplasmic reticulum (ER) exit sites (ERES) involves the formation of
phosphatidylinositol‐4 phosphate (PI4) and Sec16, but it is entirely unknown how ERES adapt …

INTRODUCTION The unfolded protein response (UPR) maintains homeostasis of the
endoplasmic reticulum (ER) through a variety of mechanisms, including ER-associated …

Hereditary spastic paraplegias (HSPs) are a diverse group of neurodegenerative diseases
that are characterized by axonopathy of the corticospinal motor neurons. A mutation in the …

Mechanobiology studies the mechanisms by which cells sense and respond to physical
forces, and the role of these forces in shaping cells and tissues themselves. Mechanosensing …