Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

R Visse, H Nagase - Circulation research, 2003 - Am Heart Assoc
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the
extracellular matrix. These proteinases play a central role in many biological processes, …

Matrix metalloproteinases

H Nagase - Zinc metalloproteases in health and disease, 1996 - taylorfrancis.com
Matrix metalloproteinases (MMPs), also designated matnxms, are a family of related zinc
metalloendopeptidases that function in the turnover of components of the extracellular matrix. …

Structure and function of matrix metalloproteinases and TIMPs

H Nagase, R Visse, G Murphy - Cardiovascular research, 2006 - academic.oup.com
Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular
environment of cells and degrade both matrix and non-matrix proteins. They play central roles in …

[HTML][HTML] Tissue inhibitors of metalloproteinases: evolution, structure and function

K Brew, D Dinakarpandian, H Nagase - Biochimica et Biophysica Acta (BBA …, 2000 - Elsevier
The matrix metalloproteinases (MMPs) play a key role in the normal physiology of connective
tissue during development, morphogenesis and wound healing, but their unregulated …

Activation mechanisms of matrix metalloproteinases.

H Nagase - Biological chemistry, 1997 - europepmc.org
Matrix metalloproteinases (MMPs), also called matrixins, function in the turnover of extracellular
matrix components. These enzymes are considered to play important roles in embryo …

[HTML][HTML] The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity

K Brew, H Nagase - Biochimica et biophysica acta (BBA)-molecular cell …, 2010 - Elsevier
Tissue inhibitors of metalloproteinases (TIMPs) are widely distributed in the animal kingdom
and the human genome contains four paralogous genes encoding TIMPs 1 to 4. TIMPs …

Progress in matrix metalloproteinase research

G Murphy, H Nagase - Molecular aspects of medicine, 2008 - Elsevier
Matrix metalloproteinases (MMPs) are now acknowledged as key players in the regulation
of both cell–cell and cell–extracellular matrix interactions. They are involved in modifying …

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

…, A Bergner, R Huber, K Suzuki, N Yoshida, H Nagase… - Nature, 1997 - nature.com
Matrix metalloproteinases (MMPs) are zinc endopeptidases that are required for the
degradation of extracellular matrix components during normal embryo development, …

[HTML][HTML] Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

Y Ogata, JJ Enghild, H Nagase - Journal of Biological Chemistry, 1992 - Elsevier
Matrix metalloproteinase 9 (MMP-9), also known as 92-kDa gelatinase/type IV collagenase,
is secreted from neutrophils, macrophages, and a number of transformed cells in zymogen …

[HTML][HTML] Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion

…, E Hahn-Dantona, J Sipley, H Nagase… - Journal of Biological …, 1999 - ASBMB
Matrix metalloproteinase-9 (MMP-9) may play a critical catalytic role in tissue remodeling in
vivo, but it is secreted by cells as a stable, inactive zymogen, pro-MMP-9, and requires …