User profiles for Hideki Mizutani
 | Hideki Mizutani金城学院大学薬学部 Verified email at umin.ac.jp Cited by 1542 |
Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
H Mizutani, S Tada-Oikawa, Y Hiraku, M Kojima… - Life sciences, 2005 - Elsevier
The main anticancer action of doxorubicin (DOX) is believed to be due to topoisomerase II
inhibition and free radical generation. Our previous study has demonstrated that TAS-103, a …
inhibition and free radical generation. Our previous study has demonstrated that TAS-103, a …
A bovine low molecular weight bone morphogenetic protein (BMP) fraction.
MR Urist, A LIETZE, H MIZUTANI… - … Research (1976-2007 …, 1982 - journals.lww.com
METHODS Ten kilograms of cortical bone were obtained from one-year-old steers at an
abattoire. The bones were mechanically scraped clean of soft tis-sue, frozen in liquid N,, ground …
abattoire. The bones were mechanically scraped clean of soft tis-sue, frozen in liquid N,, ground …
DNA intrastrand cross‐link at the 5′‐GA‐3′ sequence formed by busulfan and its role in the cytotoxic effect
T Iwamoto, Y Hiraku, S Oikawa, H Mizutani… - Cancer …, 2004 - Wiley Online Library
Busulfan (1,4‐butanediol dimethanesulfonate) has been used widely for the treatment of
patients with chronic myelogenous leukemia. Busulfan is bifunctional and thus may effectively …
patients with chronic myelogenous leukemia. Busulfan is bifunctional and thus may effectively …
Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells
…, H Nakashima, T Okuda, H Mizutani… - Proceedings of the …, 2005 - National Acad Sciences
Although ganglioside GD3 levels are highly elevated in malignant melanomas, the role of
GD3 in melanomas' malignant properties has not been clearly shown. To investigate this …
GD3 in melanomas' malignant properties has not been clearly shown. To investigate this …
The safety and efficacy of weekly paclitaxel in combination with carboplatin for advanced non-small cell lung cancer with idiopathic interstitial pneumonias
Y Minegishi, J Sudoh, H Kuribayasi, H Mizutani… - Lung cancer, 2011 - Elsevier
BACKGROUND: Idiopathic interstitial pneumonias (IIPs) are one of the most common
complications in patients with lung cancer. In lung cancer patients with IIP, the most serious toxicity …
complications in patients with lung cancer. In lung cancer patients with IIP, the most serious toxicity …
Exacerbation of idiopathic interstitial pneumonias associated with lung cancer therapy
Y Minegishi, K Takenaka, H Mizutani, J Sudoh… - Internal …, 2009 - jstage.jst.go.jp
Objective and Methods Idiopathic interstitial pneumonias (IIPs) frequently occur in
association with lung cancer. However, there is no consensus on the best treatment of acute …
association with lung cancer. However, there is no consensus on the best treatment of acute …
MicroRNA-145 post-transcriptionally regulates the expression and function of P-glycoprotein in intestinal epithelial cells
K Ikemura, M Yamamoto, S Miyazaki, H Mizutani… - Molecular …, 2013 - ASPET
P-glycoprotein (P-gp/MDR1) is a multispecific efflux transporter regulating the pharmacokinetics
of various drugs. Although P-gp expression in the small intestine is elevated after liver …
of various drugs. Although P-gp expression in the small intestine is elevated after liver …
Immunohistochemical study of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2,-4 (BMP-2,-4) on lengthened rat femurs
K Sojo, Y Sawaki, H Hattori, H Mizutani… - Journal of Cranio …, 2005 - Elsevier
BACKGROUND: With a hypothesis that “angiogenesis occurs before osteogenesis,” an
experimental study using a rat model was carried out. Histological and immunohistochemical …
experimental study using a rat model was carried out. Histological and immunohistochemical …
[HTML][HTML] The feasibility study of Carboplatin plus Etoposide for advanced small cell lung cancer with idiopathic interstitial pneumonias
…, H Kuribayashi, K Kitamura, H Mizutani… - Journal of Thoracic …, 2011 - Elsevier
Background: Idiopathic interstitial pneumonias (IIPs) are among the most common complications
in patients with lung cancer. In such patients with cancer, the most serious expression …
in patients with lung cancer. In such patients with cancer, the most serious expression …
Pirarubicin, an anthracycline anticancer agent, induces apoptosis through generation of hydrogen peroxide
H Mizutani, S Hotta, A Nishimoto, K Ikemura… - Anticancer …, 2017 - ar.iiarjournals.org
Background/Aim: Pirarubicin (THP) has shown equal or superior cytotoxicity compared to
doxorubicin. One of the main anticancer actions of doxorubicin is believed to be involved in …
doxorubicin. One of the main anticancer actions of doxorubicin is believed to be involved in …