Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors
…, M Yagi, M Sato, R Suzuki, H Murooka… - Molecular …, 2003 - ASPET
Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors:
three subtypes of the EDG-family receptors, LPA 1 , LPA 2 , and LPA 3 (formerly known …
three subtypes of the EDG-family receptors, LPA 1 , LPA 2 , and LPA 3 (formerly known …
Novel Potent Orally Active Selective VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of N-Phenyl-N'-{4-(4 …
K Kubo, T Shimizu, S Ohyama, H Murooka… - Journal of medicinal …, 2005 - ACS Publications
N-Phenyl-N‘-{4-(4-quinolyloxy)phenyl}ureas were found to be a novel class of potent inhibitors
for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase through …
for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase through …
A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model
H Ohno, K Kubo, H Murooka, Y Kobayashi… - Molecular cancer …, 2006 - AACR
In bone metastatic lesions, osteoclasts play a key role in the development of osteolysis. Previous
studies have shown that macrophage colony-stimulating factor (M-CSF) is important for …
studies have shown that macrophage colony-stimulating factor (M-CSF) is important for …
The orally‐active and selective c‐Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen‐induced arthritis mouse model
H Ohno, Y Uemura, H Murooka… - European journal of …, 2008 - Wiley Online Library
Macrophage colony‐stimulating factor (M‐CSF) is important in the development of macrophages
and osteoclasts. Previous studies have also shown that CD11b + myeloblasts and …
and osteoclasts. Previous studies have also shown that CD11b + myeloblasts and …
The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis
…, H Ohno, Y Ohzeki, H Takanashi, H Murooka… - Journal of …, 2008 - Elsevier
Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS),
can be induced by the immunization of mice with myelin antigens in the form of myelin …
can be induced by the immunization of mice with myelin antigens in the form of myelin …
Orally active anti-proliferation agents: novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors
…, T Nishitoba, K Kimura, T Senga, H Murooka… - Bioorganic & medicinal …, 2004 - Elsevier
(6,7-Disubstituted-quinolin-4-yloxy-phenyl)(4-substituted-phenyl)amine derivatives were
synthesized and evaluated by a cellular autophosphorylation assay for FGF-R2 in the human …
synthesized and evaluated by a cellular autophosphorylation assay for FGF-R2 in the human …
Synthesis and structure–activity relationship for new series of 4-Phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine …
…, S Ohyama, T Shimizu, A Takami, H Murooka… - Bioorganic & medicinal …, 2003 - Elsevier
We discovered a new series of 4-phenoxyquinoline derivatives as potent and selective
inhibitors of the platelet-derived growth factor receptor (PDGFr) tyrosine kinase. We researched …
inhibitors of the platelet-derived growth factor receptor (PDGFr) tyrosine kinase. We researched …
A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation
K Kubo, T Shimizu, S Ohyama, H Murooka… - Bioorganic & Medicinal …, 1997 - Elsevier
A novel series of 4-phenoxyquinolines, some of which showed potent and highly selective
inhibitory activities for PDGF receptor autophosphorylation, was discovered. Interestingly, …
inhibitory activities for PDGF receptor autophosphorylation, was discovered. Interestingly, …
Beneficial effects of a novel inhibitor of platelet-derived growth factor receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis
…, K Nakamura, K Kubo, SI Ohyama, H Murooka… - … : The Vascular System, 1998 - Elsevier
Our original compound, Ki6896 ((4-t-butylphenyl){4-[(6,7-dimethoxy-4-quinolyl) oxy]phenyl}
methanone) strongly inhibited the autophosphorylation of platelet-derived growth factor (…
methanone) strongly inhibited the autophosphorylation of platelet-derived growth factor (…
[HTML][HTML] Luminespib inhibitor
…, M YAGI, M SATO, R SUZUKI, H MUROOKA… - luminespibinhibitor.com
Lysophosphatidic acid (LPA) exerts a variety of biological re-sponses through specific receptors:
three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as …
three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as …