The transcription factor E2F-1 drives proliferation and death, but the mechanisms that
differentially regulate these divergent actions are poorly understood. The hypoxia-inducible death …

Myocardial ischemia and angiotensin II activate the tumor suppressor p53 protein, which
promotes cell death. Previously, we showed that the Bcl-2 death gene Bnip3 is highly induced …

Background: Cytokines such as tumor necrosis factor-α (TNFα) have been implicated in
cardiac dysfunction and toxicity associated with doxorubicin (DOX). Although TNFα can elicit …

Aims The chemotherapy drug doxorubicin (Dox) is commonly used for treating a variety of
human cancers; however, it is highly cardiotoxic and induces heart failure. We previously …

Background— Tumor necrosis factor-α and other proinflammatory cytokines activate the
canonical Nuclear Factor (NF)-κB pathway through the kinase IKKβ. Previously, we established …

The use of cocaine causes cardiac arrhythmias and sudden death. Blockade of the cardiac
potassium channel human ether-á-go-go-related gene (hERG) has been implicated as a …

Rationale: Alternative splicing provides a versatile mechanism by which cells generate
proteins with different or even antagonistic properties. Previously, we established hypoxia-…

Herein we describe a novel survival pathway that operationally links alternative pre-mRNA
splicing of the hypoxia-inducible death protein Bcl-2 19-kD interacting protein 3 (Bnip3) to the …

Autophagy is a highly orchestrated cellular process by which proteins and organelles are
degraded via an elaborate lysosomal pathway to generate free amino acids and sugars for …

Aims The mitochondrial dynamics protein Mitofusin 2 (MFN2) coordinates critical cellular
processes including mitochondrial bioenergetics, quality control, and cell viability. The NF-κB …