GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies
LM Dibbens, HJ Feng, MC Richards… - Human molecular …, 2004 - academic.oup.com
A major challenge in understanding complex idiopathic generalized epilepsies has been
the characterization of their underlying molecular genetic basis. Here, we report that genetic …
the characterization of their underlying molecular genetic basis. Here, we report that genetic …
Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse …
Sudden unexpected death in epilepsy (SUDEP) is a devastating epilepsy complication.
Seizure-induced respiratory arrest (S-IRA) occurs in many witnessed SUDEP patients and …
Seizure-induced respiratory arrest (S-IRA) occurs in many witnessed SUDEP patients and …
GABAA receptor epilepsy mutations
RL Macdonald, MJ Gallagher, HJ Feng… - Biochemical pharmacology, 2004 - Elsevier
Idiopathic generalized epilepsy (IGE) syndromes are diseases that are characterized by
absence, myoclonic, and/or primary generalized tonic-clonic seizures in the absence of …
absence, myoclonic, and/or primary generalized tonic-clonic seizures in the absence of …
δ subunit susceptibility variants E177A and R220H associated with complex epilepsy alter channel gating and surface expression of α4β2δ GABAA receptors
HJ Feng, JQ Kang, L Song, L Dibbens… - Journal of …, 2006 - Soc Neuroscience
Most human idiopathic generalized epilepsies (IGEs) are polygenic, but virtually nothing is
known of the molecular basis for any of the complex epilepsies. Recently, two GABA A …
known of the molecular basis for any of the complex epilepsies. Recently, two GABA A …
Pentobarbital differentially modulates α1β3δ and α1β3γ2L GABAA receptor currents
HJ Feng, MT Bianchi, RL Macdonald - Molecular pharmacology, 2004 - ASPET
GABA A receptors are modulated by a variety of compounds, including the neurosteroids
and barbiturates. Although the effects of barbiturates on αβγ isoforms, thought to dominate …
and barbiturates. Although the effects of barbiturates on αβγ isoforms, thought to dominate …
Abnormalities of serotonergic neurotransmission in animal models of SUDEP
HJ Feng, CL Faingold - Epilepsy & Behavior, 2017 - Elsevier
Sudden unexpected death in epilepsy (SUDEP) is a devastating event, and both DBA/1 and
DBA/2 mice have been shown to be relevant animal models for studying SUDEP. DBA mice …
DBA/2 mice have been shown to be relevant animal models for studying SUDEP. DBA mice …
[HTML][HTML] Testosterone attenuates sevoflurane-induced tau phosphorylation and cognitive impairment in neonatal male mice
…, Y Zhang, G Yang, SG Soriano, HJ Feng… - British Journal of …, 2021 - Elsevier
Background Sevoflurane anaesthesia induces phosphorylation of the microtubule-associated
protein tau and cognitive impairment in neonatal, but not adult, mice. The underlying …
protein tau and cognitive impairment in neonatal, but not adult, mice. The underlying …
A unified hypothesis of SUDEP: Seizure‐induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and …
CL Faingold, HJ Feng - Epilepsia, 2023 - Wiley Online Library
Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in people with
epilepsy (PWE). Postictal apnea leading to cardiac arrest is the most common sequence of …
epilepsy (PWE). Postictal apnea leading to cardiac arrest is the most common sequence of …
5‐Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure‐induced respiratory arrest
…, H Zhao, X Yang, Q Xue, JF Cotten, HJ Feng - …, 2016 - Wiley Online Library
Objective The DBA/1 mouse is a relevant animal model of sudden unexpected death in
epilepsy (SUDEP), as it exhibits seizure‐induced respiratory arrest (S‐IRA) evoked by acoustic …
epilepsy (SUDEP), as it exhibits seizure‐induced respiratory arrest (S‐IRA) evoked by acoustic …
Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice
Sudden unexpected death in epilepsy (SUDEP) is a fatal epileptic event. DBA/1 mice are a
relevant animal model for the study of SUDEP, as these mice exhibit seizure-induced …
relevant animal model for the study of SUDEP, as these mice exhibit seizure-induced …