Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most
of the anti-cancer therapies trigger apoptosis induction and related cell death networks to …

Cancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG),
have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea …

Terpenoids represent a large and diverse class of naturally occurring compounds found in a
variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are …

Interest in the use of traditional medicines for cancer prevention and treatment is increasing.
In vitro, in vivo, and clinical studies suggest the potential use of proteasome inhibitors as …

Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an
inhibitor of aldehyde dehydrogenase, is currently being used clinically for the treatment of …

Nitric oxide ( NO ) and reactive oxygen species ( ROS ) are two classes of key signaling
molecules involved in various developmental processes and stress responses in plants. The …

Withaferin A (WA) is a steroidal lactone purified from medicinal plant “Indian Winter Cherry”
that is widely researched for its variety of properties, including antitumor effects. However, the …

Tumor growth and metastasis depend on angiogenesis that requires the cofactor copper.
Consistently, high levels of copper have been found in many types of human cancers, …

Dysregulation of the ubiquitin‐proteasome pathway plays an essential role in tumor growth
and development. Shikonin, a natural naphthoquinone isolated from the traditional Chinese …

A major challenge in cancer therapy is tumor drug resistance. To overcome it, it is essential
to understand the mechanisms and identify the molecules involved, so that they can be …