[HTML][HTML] Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase
HP Cho, MT Nakamura, SD Clarke - Journal of Biological Chemistry, 1999 - ASBMB
Arachidonic acid (20:4(n-6)) and docosahexaenoic acid (22:6(n-3)) have a variety of physiological
functions that include being the major component of membrane phospholipid in brain …
functions that include being the major component of membrane phospholipid in brain …
[HTML][HTML] Cloning, expression, and fatty acid regulation of the human Δ-5 desaturase
HP Cho, M Nakamura, SD Clarke - Journal of Biological Chemistry, 1999 - ASBMB
Arachidonic (20:4(n-6)), eicosapentaenoic (20:5(n-3)), and docosahexaenoic (22:6(n-3))
acids are major components of brain and retina phospholipids, substrates for eicosanoid …
acids are major components of brain and retina phospholipids, substrates for eicosanoid …
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic
glutamate receptors (mGlus), which are class CG protein–coupled receptors (GPCRs). We …
glutamate receptors (mGlus), which are class CG protein–coupled receptors (GPCRs). We …
[HTML][HTML] Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids: a mechanism for the coordinate suppression of …
J Xu, MT Nakamura, HP Cho, SD Clarke - Journal of Biological Chemistry, 1999 - ASBMB
Polyunsaturated fatty acids (PUFA) coordinately suppress the transcription of a wide array
of hepatic lipogenic genes including fatty acid synthase (FAS) and acetyl-CoA carboxylase. …
of hepatic lipogenic genes including fatty acid synthase (FAS) and acetyl-CoA carboxylase. …
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness
SA Scott, PE Selvy, JR Buck, HP Cho… - Nature chemical …, 2009 - nature.com
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid
second messenger phosphatidic acid. Phosphatidic acid participates in both G protein–…
second messenger phosphatidic acid. Phosphatidic acid participates in both G protein–…
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous …
MJ Noetzel, JM Rook, PN Vinson, HP Cho, E Days… - Molecular …, 2012 - ASPET
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGlu 5
) have emerged as an exciting new approach for the treatment of schizophrenia and other …
) have emerged as an exciting new approach for the treatment of schizophrenia and other …
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models
…, EP Lebois, Z Xiang, DJ Sheffler, HP Cho… - Journal of …, 2012 - Soc Neuroscience
M 1 muscarinic acetylcholine receptors (mAChRs) represent a viable target for treatment of
multiple disorders of the central nervous system (CNS) including Alzheimer's disease and …
multiple disorders of the central nervous system (CNS) including Alzheimer's disease and …
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity
…, WA Pouliot, TM Bridges, PN Vinson, HP Cho… - Biological …, 2013 - Elsevier
BACKGROUND: Metabotropic glutamate receptor subtype 5 (mGlu 5 ) activators have
emerged as a novel approach to the treatment of schizophrenia. Positive allosteric modulators (…
emerged as a novel approach to the treatment of schizophrenia. Positive allosteric modulators (…
M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
SP Moran, JW Dickerson, HP Cho, Z Xiang… - …, 2018 - nature.com
Highly selective positive allosteric modulators (PAMs) of the M 1 subtype of muscarinic
acetylcholine receptor have emerged as an exciting new approach for improving cognitive …
acetylcholine receptor have emerged as an exciting new approach for improving cognitive …
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor:(S)-9b-(4-chlorophenyl)-1-(3, 4 …
…, JM Harp, HP Cho, E Smith, P Chase… - Journal of medicinal …, 2013 - ACS Publications
A functional high throughput screen and subsequent multidimensional, iterative parallel
synthesis effort identified the first muscarinic acetylcholine receptor (mAChR) negative allosteric …
synthesis effort identified the first muscarinic acetylcholine receptor (mAChR) negative allosteric …