Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but
ubiquitous expression causes obesity. An expressed sequence tag was identified that …

Importance Sodium-glucose cotransporter 2 (SGLT2) inhibitors favorably affect cardiovascular
(CV) and kidney outcomes; however, the consistency of outcomes across the class …

Background The cardiovascular effects of ertugliflozin, an inhibitor of sodium–glucose
cotransporter 2, have not been established. Methods In a multicenter, double-blind trial, we …

The recent cloning of three melanocortin receptors suggests an unexpected diversity in this
family of seven transmembrane G-protein linked receptors. Herein, we report the cloning, …

The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin
gene, five melanocortin receptors, two endogenous antagonists, and two ancillary …

… Kaelin,3 Heidi EW Day,1 Michael Ollmann,3 Ira Gantz,2 Huda Akil,1 Gregory S. Barsh,3 and
… Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS (1997) Antagonism …

The H2 subclass of histamine receptors mediates gastric acid secretion, and antagonists for
this receptor have proven to be effective therapy for acid peptic disorders of the …

We report the isolation of a gene encoding a novel member of the family of melanocortin
receptors. The mouse melanocortin-5 receptor (mMC5R) responds to melanocortins with an …

Background: In patients with type 2 diabetes mellitus, sodium-glucose cotransporter 2
inhibitors reduce the risk of hospitalization for heart failure (HHF). We assessed the effect of …

Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin
receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice…