Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved

…, T Wallerath, C Euchenhofer, I Ihrig-Biedert… - …, 1998 - Am Heart Assoc
Estrogens have been found to reduce the incidence of cardiovascular disease that has been
ascribed in part to an increased expression and/or activity of the vasoprotective endothelial …

Cytokine induction of NO synthase II in human DLD‐1 cells: roles of the JAK‐STAT, AP‐1 and NF‐κB‐signaling pathways

…, T Wallerath, G Fritz, I IhrigBiedert… - British journal of …, 1998 - Wiley Online Library
1 In human epithelial‐like DLD‐1 cells, nitric oxide synthase (NOS) II expression was
induced by interferon‐γ (100 u ml −1 ) alone and, to a larger extent, by a cytokine mixture (CM) …

[HTML][HTML] Complex contribution of the 3′-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene: involvement of the RNA …

…, M Hausding, I Ihrig-Biedert… - Journal of Biological …, 2000 - ASBMB
Cytokine stimulation of human DLD-1 cells resulted in a marked expression of nitric-oxide
synthase (NOS) II mRNA and protein accompanied by only a moderate increase in …

Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.

H Kleinert, C Euchenhofer, I Ihrig-Biedert… - Molecular …, 1996 - ASPET
Incubation of human A549/8 cells with human interleukin-1 beta (50 units/ml), interferon-gamma
(100 units/ml), and tumor necrosis factor-alpha (10 ng/ml) (cytomix) resulted in a marked …

Activation of protein kinase Cα and/or ε enhances transcription of the human endothelial nitric oxide synthase gene

H Li, SA Oehrlein, T Wallerath, I Ihrig-Biedert… - Molecular …, 1998 - ASPET
In primary human umbilical vein endothelial cells (HUVECs), incubation with phorbol-12-myristate-13-acetate
(PMA) enhanced basal and bradykinin-stimulated nitric oxide production. …

[HTML][HTML] In Murine 3T3 Fibroblasts, Different Second Messenger Pathways Resulting in the Induction of NO Synthase II (iNOS) Converge in the Activation of …

H Kleinert, C Euchenhofer, I Ihrig-Biedert… - Journal of Biological …, 1996 - ASBMB
Transcription factor NF-κB is essential for the induction of nitric oxide synthase (NOS) II (iNOS)
by bacterial lipopolysaccharide in murine macrophages (Xie, QW, Kashiwabara, Y., and …

Involvement of protein kinases in the induction of NO synthase II in human DLD‐1 cells

…, C Euchenhofer, G Fritz, I IhrigBiedert… - British journal of …, 1998 - Wiley Online Library
Protein phosphorylation is involved in the induction of nitric oxide synthase II (NOS II, iNOS)
in several types of animal cells. Here we have investigated the possible involvement of …

[HTML][HTML] NOX2ko mice show largely increased expression of a mutated NOX2 mRNA encoding an inactive NOX2 protein

M Göllner, I Ihrig-Biedert, V Petermann, S Saurin… - Antioxidants, 2020 - mdpi.com
Background: The superoxide-generating enzyme nicotinamide adenine dinucleotide phosphate
(NADPH) oxidase (NOX2 or gp91phox, the phagocytic isoform) was reported as a major …

[HTML][HTML] A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into …

F Gather, I Ihrig-Biedert, P Kohlhas, T Krutenko… - Cell Communication and …, 2022 - Springer
Background NOS2 expression is mostly found in bacteria-exposed or cytokine-treated tissues
and is mostly connected to innate immune reactions. There are three isoforms of NOS2 (…

A non-immune form of the enzyme NOS2 is expressed during stem cell differentiation

F Gather, I Ihrig-Biedert, P Kohlhas, T Krutenko, M Peitz… - 2022 - researchsquare.com
The enzyme NOS2 produces nitric oxide, a signaling molecule involved in processes like
blood pressure regulation, immunity, and stem cell differentiation. NOS2 has three isoforms (…