User profiles for Isaac N. Pessah

Isaac Pessah

University of California, Davis
Verified email at ucdavis.edu
Cited by 26582

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism

…, R Nguyen, L Pavinato, M Pericak-Vance, IN Pessah… - Nature …, 2022 - nature.com
Some individuals with autism spectrum disorder (ASD) carry functional mutations rarely
observed in the general population. We explored the genes disrupted by these variants from …

[HTML][HTML] Xestospongins: potent membrane permeable blockers of the inositol 1, 4, 5-trisphosphate receptor

…, TH Lam, MC Catlin, LG Costa, TF Molinski, IN Pessah - Neuron, 1997 - cell.com
Isaac N Pessah Isaac N Pessah … elongated core with two partially charged N groups at
either end, provide an ideal lipophilic/hydrophilic moiety to fit into the IP 3 R channel pore. …

Mitochondrial dysfunction in autism

…, S Wong, I Hertz-Picciotto, F Tassone, IN Pessah - Jama, 2010 - jamanetwork.com
Context Impaired mitochondrial function may influence processes highly dependent on
energy, such as neurodevelopment, and contribute to autism. No studies have evaluated …

Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor

J Nakai, RT Dirksen, HT Nguyen, IN Pessah, KG Beam… - Nature, 1996 - nature.com
EXCITATION-CONTRACTION coupling in skeletal muscle involves a voltage sensor in the
plasma membrane which, in response to depolarization, causes an intracellular calcium-…

The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism

…, CR Jones, J Van de Water, IN Pessah - Environmental …, 2006 - ehp.niehs.nih.gov
Causes and contributing factors for autism are poorly understood. Evidence suggests that
prevalence is rising, but the extent to which diagnostic changes and improvements in …

In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens

…, MS Denison, B Lasley, IN Pessah… - Environmental …, 2008 - ehp.niehs.nih.gov
Background Concerns have been raised about the biological and toxicologic effects of the
antimicrobials triclocarban (TCC) and triclosan (TCS) in personal care products. Few studies …

The calcium-ryanodine receptor complex of skeletal and cardiac muscle

IN Pessah, AL Waterhouse, JE Casida - Biochemical and biophysical …, 1985 - Elsevier
[ 3 H]Ryanodine binds with high affinity to saturable and Ca 2+ -dependent sites in heavy
sarcoplasmic reticulum (SR) preparations from rabbit skeletal and cardiac muscle. Ruthenium …

Autism: maternally derived antibodies specific for fetal brain proteins

…, I Hertz-Picciotto, R Hansen, LA Croen, IN Pessah… - Neurotoxicology, 2008 - Elsevier
Autism is a profound disorder of neurodevelopment with poorly understood biological origins.
A potential role for maternal autoantibodies in the etiology of some cases of autism has …

Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders

…, I Hertz-Picciotto, R Hansen, IN Pessah… - Journal of …, 2011 - Elsevier
A role for immune dysfunction has been suggested in autism spectrum disorders (ASD).
Elevated levels of chemokines have been detected in the brain and CSF of individuals with ASD …

Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2, 3-dioxygenase

CFA Vogel, SR Goth, B Dong, IN Pessah… - Biochemical and …, 2008 - Elsevier
Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzio-p-dioxin (TCDD)
leads to immune suppression associated with the induction of regulatory T cells (T reg ) …