Opiates such as morphine are the choice analgesic in the treatment of chronic pain. However
their long-term use is limited because of the development of tolerance and dependence. …

Several studies have described functional interactions between opioid and cannabinoid
receptors; the underlying mechanism (s) have not been well explored. One possible mechanism …

G protein–coupled receptors (GPCRs) compose one of the largest families of membrane
proteins involved in intracellular signaling. They are involved in numerous physiological and …

To date, the endogenous ligands described for cannabinoid receptors have been derived
from membrane lipids. To identify a peptide ligand for CB 1 cannabinoid receptors, we used …

The dopamine transporter (DAT) terminates dopamine (DA) neurotransmission by reuptake
of DA into presynaptic neurons. Regulation of DA uptake by D 2 dopamine receptors (D 2 R) …

The μ and δ types of opioid receptors form heteromers that exhibit pharmacological and
functional properties distinct from those of homomeric receptors. To characterize these …

Objetivo: comparar o potencial elétrico do músculo masseter durante a trituração de
alimentos com rigidez variada em indivíduos com oclusão clinicamente normal. Métodos: dez …

Antidepressants are commonly used in the treatment of anxiety and depression, medical
conditions that affect ∼17–20% of the population. The clinical effects of antidepressants take …

The mechanism of G protein‐coupled receptor (GPCR) signal integration is controversial.
While GPCR assembly into hetero‐oligomers facilitates signal integration of different receptor …

Objetivo: investigar a percepção do gosto salgado percebido pelos indivíduos com obstrução
nasal em comparação aos indivíduos sem obstrução nasal. Métodos: foram avaliados 54 …