The purpose of this review is to provide an account of the physiological substrates of cAMP-dependent
protein kinase (PKA). Discussion is limited to just over 100 unique gene products …

Melanoma and other cancers harbor oncogenic mutations in the protein kinase B-Raf,
which leads to constitutive activation and dysregulation of MAP kinase signaling. In order to …

Significant differences in biochemical parameters between normal and tumor tissues offer an
opportunity to chemically design drug carriers which respond to these changes and deliver …

Liposomes have been widely used as a drug delivery vehicle, and currently, more than 10
liposomal formulations are approved by the Food and Drug Administration for clinical use. …

Improving the therapeutic index of anticancer agents is an enormous challenge. Targeting
decreases the side effects of the therapeutic agents by delivering the drugs to the intended …

Proteomics addresses the important goal of determining the chemistry and composition of
proteins in biological samples. Mass-spectrometry-based strategies have been highly …

Promoter elements important for basal and cyclic AMP (cAMP)-regulated expression of the
phosphoenolpyruvate carboxykinase (PEPCK) gene have been identified by analysis of a …

The aim of this study is to illuminate a novel therapeutic approach by identifying a functional
binding target of salinomycin, an emerging anticancer stem cell (CSC) agent, and to help …

Revised Manuscript Received April 3, 1989 abstract: Mammalian cGMP-and cAMP-dependent
protein kinases show considerable similarity in amino acid sequence, although they …

Human metallothioneins (MTs) are important regulators of metal homeostasis and protectors
against oxidative damage. Their altered mRNA expression has been correlated with metal …