The rapid evolution of drug discovery science, fuelled by combinatorial librarybased synthesis
programmes, has led to increased pressure on the drug safety evaluation process. Once …

The later that a molecule or molecular class is lost from the drug development pipeline, the
higher the financial cost. Minimizing attrition is therefore one of the most important aims of a …

High resolution one-and multi-dimensional NMR spectra measured on biological samples
can be extremely complex. For example, for pure proteins in solution, and for biofluids and …

There is a general consensus that supports the need for standardized reporting of metadata
or information describing large-scale metabolomics and other functional genomics data sets…

… Lindon, JC & Holmes, E. A survey of metabonomics approaches for disease characterization…
Liu, M., Nicholson, JK & Lindon, JC High resolution diffusion and relaxation edited one- and …

Organisms often respond in complex and unpredictable ways to stimuli that cause disease
or injury. By measuring and mathematically modelling changes in the levels of products of …

Here, we study the intricate relationship between gut microbiota and host cometabolic phenotypes
associated with dietary-induced impaired glucose homeostasis and nonalcoholic fatty …

High-resolution 750 MHz 1H NMR spectra of control human blood plasma have been
measured and assigned by the concerted use of a range of spin-echo, two-dimensional J-resolved…

There is a clear case for drug treatments to be selected according to the characteristics of
an individual patient, in order to improve efficacy and reduce the number and severity of …

We describe here the implementation of the statistical total correlation spectroscopy (STOCSY)
analysis method for aiding the identification of potential biomarker molecules in …