User profiles for J C Lindon
Lindon JCVerified email at imperial.ac.uk Cited by 64860 |
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR …
The rapid evolution of drug discovery science, fuelled by combinatorial librarybased synthesis
programmes, has led to increased pressure on the drug safety evaluation process. Once …
programmes, has led to increased pressure on the drug safety evaluation process. Once …
Metabonomics: a platform for studying drug toxicity and gene function
JK Nicholson, J Connelly, JC Lindon… - Nature reviews Drug …, 2002 - nature.com
The later that a molecule or molecular class is lost from the drug development pipeline, the
higher the financial cost. Minimizing attrition is therefore one of the most important aims of a …
higher the financial cost. Minimizing attrition is therefore one of the most important aims of a …
Pattern recognition methods and applications in biomedical magnetic resonance
High resolution one-and multi-dimensional NMR spectra measured on biological samples
can be extremely complex. For example, for pure proteins in solution, and for biofluids and …
can be extremely complex. For example, for pure proteins in solution, and for biofluids and …
[HTML][HTML] Proposed minimum reporting standards for chemical analysis: chemical analysis working group (CAWG) metabolomics standards initiative (MSI)
There is a general consensus that supports the need for standardized reporting of metadata
or information describing large-scale metabolomics and other functional genomics data sets…
or information describing large-scale metabolomics and other functional genomics data sets…
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
… Lindon, JC & Holmes, E. A survey of metabonomics approaches for disease characterization…
Liu, M., Nicholson, JK & Lindon, JC High resolution diffusion and relaxation edited one- and …
Liu, M., Nicholson, JK & Lindon, JC High resolution diffusion and relaxation edited one- and …
Metabonomics
JK Nicholson, JC Lindon - Nature, 2008 - nature.com
Organisms often respond in complex and unpredictable ways to stimuli that cause disease
or injury. By measuring and mathematically modelling changes in the levels of products of …
or injury. By measuring and mathematically modelling changes in the levels of products of …
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
…, R Tatoud, V Blanc, JC Lindon… - Proceedings of the …, 2006 - National Acad Sciences
Here, we study the intricate relationship between gut microbiota and host cometabolic phenotypes
associated with dietary-induced impaired glucose homeostasis and nonalcoholic fatty …
associated with dietary-induced impaired glucose homeostasis and nonalcoholic fatty …
750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma
…, PJD Foxall, M Spraul, RD Farrant, JC Lindon - Analytical …, 1995 - ACS Publications
High-resolution 750 MHz 1H NMR spectra of control human blood plasma have been
measured and assigned by the concerted use of a range of spin-echo, two-dimensional J-resolved…
measured and assigned by the concerted use of a range of spin-echo, two-dimensional J-resolved…
Pharmaco-metabonomic phenotyping and personalized drug treatment
There is a clear case for drug treatments to be selected according to the characteristics of
an individual patient, in order to improve efficacy and reduce the number and severity of …
an individual patient, in order to improve efficacy and reduce the number and severity of …
Statistical Total Correlation Spectroscopy: An Exploratory Approach for Latent Biomarker Identification from Metabolic 1H NMR Data Sets
…, C Blancher, D Gauguier, JC Lindon… - Analytical …, 2005 - ACS Publications
We describe here the implementation of the statistical total correlation spectroscopy (STOCSY)
analysis method for aiding the identification of potential biomarker molecules in …
analysis method for aiding the identification of potential biomarker molecules in …