Hyperhomocyst(e)inemia is believed to injure endothelial cells in vivo through a number of
mechanisms, including the generation of hydrogen peroxide (H 2 O 2 ). Earlier in vitro studies …

Platelets, non-nucleated blood components first described over 130 years ago, are recognized
as the primary cell regulating hemostasis and thrombosis. The vascular importance of …

… Dr Freedman was supported by a Grant-in-Aid from the Mid-Atlantic Affiliate of the American
Heart Association, NIH grants CIDA HL-03556 and HL-61795, and a Faculty Development …

Extracellular Vesicles Circulating extracellular vesicles, which are produced by normal and
diseased tissues and released into body fluids, can be markers of disease processes and …

… Freedman is the recipient of a Grant-in-Aid from the Massachusetts Affiliate of the American
Heart Association and CIDA HL03556. John F. Keaney is the recipient of CIDA HL03195. …

Haemostasis and thrombosis are complex, multifactorial processes. There is an evolving
understanding of the mechanisms influencing vascular occlusion and the role of inflammation …

Platelet-dependent thrombus formation may be influenced by alteration of platelet or
vascular redox state, the presence of endogenous or exogenous antioxidants, as well as the …

Background Epidemiological studies indicate that vitamin E (α-tocopherol) exerts a beneficial
effect on cardiovascular disease. The effect of vitamin E has generally been attributed to its …

The angiographic severity of coronary stenoses may not predict sites of subsequent acute
coronary events, inasmuch as rupture of atheromatous plaque with thrombosis in relatively …

… Koupenova and JE Freedman designed, interpreted the results, and wrote this article. M. …
(COVID-19) rapid response grant to JE Freedman; Department of Defense grant to R. Finberg (…