Mechanistic information and structure-based design methods have been used to design a
series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus (…

Analysis of peptides by reverse-phase high-pressure liquid chromatography would be simplified
if retention times could be predicted by summing the contribution to retention of each of …

The paper explores the analysis of the geometrically nonlinear behaviour of space
structures, using the modified arc length method of Riks and Crisfield. Several problems not …

A simple, rapid method is presented for the determination of acetylcholine (ACh) and choline
(Ch) in neuronal tissue using HPLC with electrochemical detection. The method is based …

Ibotenate, a rigid structural analogue of glutamate, markedly enhances the hydrolysis of
membrane inositol phospholipids, as reflected by the stimulation of [ 3 H]inositol …

A parametric element is formulated which enables the economic modelling of ‘infinite
domain’ type problmes. A typical problem is an opening in a stress field in an infinite medium, …

Retention of small peptides (20 residues or less) on reversed-phase columns can be predicted
by summing the contribution to retention of each amino acid and end group. The high …

This paper presents summaries of the works of several authors associated with the invention
of the analysis technique now referred to as the finite element method. It stresses the notion …

Background: Effective HIV protease inhibitors must combine potency towards wild-type and
mutant variants of HIV with oral bioavailability such that drug levels in relevant tissues …

… Unfortunately, authentic serotonin-O-sulfate was not available to study this point, and could
not be synthesized by the method of Meek and NefflL When -- log Km is plotted as a function …