User profiles for J L Sussman
Joel SussmanWeizmann Institute of Science Verified email at weizmann.ac.il Cited by 44679 |
Function and structure of inherently disordered proteins
…, I Silman, VN Uversky, JL Sussman - Current opinion in …, 2008 - Elsevier
The application of bioinformatics methodologies to proteins inherently lacking 3D structure
has brought increased attention to these macromolecules. Here topics concerning these …
has brought increased attention to these macromolecules. Here topics concerning these …
Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins
M Cygler, JD Schrag, JL Sussman, M Harel… - Protein …, 1993 - Wiley Online Library
Based on the recently determined X‐ray structures of Torpedo californica acetylcholinesterase
and Geotrichum candidum lipase and on their three‐dimensional superposition, an …
and Geotrichum candidum lipase and on their three‐dimensional superposition, an …
Acetylcholinesterase:'classical'and 'non-classical'functions and pharmacology
I Silman, JL Sussman - Current opinion in pharmacology, 2005 - Elsevier
The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic
synapses by rapidly hydrolysing acetylcholine. It is anchored within the synaptic cleft by a …
synapses by rapidly hydrolysing acetylcholine. It is anchored within the synaptic cleft by a …
Atomic Structure of Acetylcholinesterase from Torpedo californica: A Prototypic Acetylcholine-Binding Protein
JL Sussman, M Harel, F Frolow, C Oefner, A Goldman… - Science, 1991 - science.org
The three-dimensional structure of acetylcholinesterase from Torpedo californica electric
organ has been determined by x-ray analysis to 2.8 angstrom resolution. The form crystallized …
organ has been determined by x-ray analysis to 2.8 angstrom resolution. The form crystallized …
The α/β hydrolase fold
…, I Silman, J Schrag, JL Sussman… - Protein Engineering …, 1992 - academic.oup.com
We have identified a new protein fold—the α/β hydrolase fold—that is common to several
hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of …
hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of …
FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded
…, O Man, JS Beckmann, I Silman, JL Sussman - …, 2005 - academic.oup.com
An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described:
it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of …
it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of …
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
…, PH Axelsen, I Silman, JL Sussman - Proceedings of the …, 1993 - National Acad Sciences
Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were
investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes …
investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes …
Three-dimensional tertiary structure of yeast phenylalanine transfer RNA
…, FL Suddath, GJ Quigley, A McPherson, JL Sussman… - Science, 1974 - science.org
The 3-angstrom electron density map of crystalline yeast phenylalanine transfer RNA has
provided us with a complete three-dimensional model which defines the positions of all of the …
provided us with a complete three-dimensional model which defines the positions of all of the …
[PDF][PDF] Structure of acetylcholinesterase complexed with E2020 (Aricept®): implications for the design of new anti-Alzheimer drugs
G Kryger, I Silman, JL Sussman - Structure, 1999 - cell.com
Background: Several cholinesterase inhibitors are either being utilized for symptomatic treatment
of Alzheimer's disease or are in advanced clinical trials. E2020, marketed as Aricept ® , …
of Alzheimer's disease or are in advanced clinical trials. E2020, marketed as Aricept ® , …
Three-dimensional structures of avidin and the avidin-biotin complex.
…, EA Bayer, M Wilchek, JL Sussman - Proceedings of the …, 1993 - National Acad Sciences
The crystal structures of a deglycosylated form of the egg-white glycoprotein avidin and of
its complex with biotin have been determined to 2.6 and 3.0 A, respectively. The structures …
its complex with biotin have been determined to 2.6 and 3.0 A, respectively. The structures …