A phytochemical investigation of the plant Vinca rosea Linn. has demonstrated that a number
of alkaloidal substances can be obtained with antitumor activity. Over 30 alkaloids have …

Escherichia coli that has been genetically manipulated by recombinant DNA technology to
synthesize human insulin polypeptides (A chain, B chain, or proinsulin) contains prominent …

The in vitro pharmacology of a structurally novel compound, LY341495, was investigated at
human recombinant metabotropic glutamate (mGlu) receptor subtypes expressed in non-…

The novel compound LY354740 is a conformationally constrained analog of glutamate, which
was designed for interaction at metabotropic glutamate (mGlu) receptors. In this paper the …

Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and
faster relapse rates relative to other breast cancer subtypes. In this report we examine the …

Anticancer nanomedicines are designed to improve anticancer efficacy by increasing drug
accumulation in tumors through enhanced permeability retention (EPR) effect, and to reduce …

Although trastuzumab is an effective treatment in early stage HER2 + breast cancer the
majority of advanced HER2 + breast cancers develop trastuzumab resistance, especially in the …

Antiangiogenic therapies inhibit the development of new tumor blood vessels, thereby blocking
tumor growth. Despite the advances in developing antiangiogenic agents, clinical data …

Aim: We aim to demonstrate that a local nanoparticle-mediated hyperthermia can effectively
eliminate tumor-associated Tregs and thereby boost checkpoint blockade-based …

Increasing evidence suggesting breast cancer stem cells (BCSCs) drive metastasis and
evade traditional therapies underscores a critical need to exploit the untapped potential of …