The N-chloro compound, dichloroisocyanuric acid (DCA), has been discharged vs. lithium
in organic nonaqueous electrolytes. The Li/2M LiC104 (methyl formate)/DCA system has an …

Flexible molecules change their conformation upon binding to a protein. This was shown by
the analysis of small molecules whose structures have been determined by X-ray …

2', 3'-Dideoxy purine nucleosides have anti-HIV activity in vitro and the inosine analogue is
being clinically evaluated. The instability of these compounds toward acidic conditions …

The mechanism of divergent anti-human immunodeficiency virus type 1 (HIV-1) activity of
various 2',3'-dideoxynucleoside analogs (ddNs) in peripheral blood mononuclear cells (PBM) …

BACKGROUND Since 1955, the National Cancer Institute (NCI), one of the US National
Institutes of Health (NIH), has conducted extensive testing of materials for possible activity …

zinc, 27 2.75 g (20 mesh, Mallinckrodt AR), was placed in a dry round-bottomed flask
equipped with a magnetic stirrer, N2 inlet, and addition funnel. A septum was attached to the …

… Earlier biochemical investigations with l-jS-D-ribofuranosyl-l,2-dihydropyrimidin-2-one (lb,
zebularine, 2(l/f)-pyrimidinone riboside), established this compound as an inhibitor of cytidine …

A series of 15 2, 5-diaziridinyl-3, 6-bis (alkylamino)-l, 4-benzoquinone derivatives was
synthesized and evaluated as central nervous system antitumor agents in the murine intracerebral …

Cyclopentenylcytosine (CPE-C, 2), a pyrimidine analogue of the fermentation derived
carbocyclic nucleoside neplanocin A, has been synthesized from the optically active …

The discovery and development of anticancer drugs with clinical potential are the responsibility
of the Developmental Therapeutics Program (DTP), Division of Cancer Treatment, …