User profiles for Jérôme Ruel

Jérôme Ruel

Aix-Marseille Université
Verified email at univ-amu.fr
Cited by 4253

[HTML][HTML] Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists

T Papouin, L Ladépêche, J Ruel, S Sacchi… - Cell, 2012 - cell.com
N-methyl-d-aspartate receptors (NMDARs) are located in neuronal cell membranes at
synaptic and extrasynaptic locations, where they are believed to mediate distinct physiological …

Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss

JL Puel, J Ruel, CG d'Aldin, R Pujol - Neuroreport, 1998 - journals.lww.com
GUINEA-PIGS were exposed to a traumatic sound inducing up to Θ dB hearing loss. Beside
the well described mechanical damage to outer hair cells, a total disruption of inner hair cell (…

Salicylate induces tinnitus through activation of cochlear NMDA receptors

MJ Guitton, J Caston, J Ruel, RM Johnson… - Journal of …, 2003 - Soc Neuroscience
Salicylate, the active component of aspirin, is known to induce tinnitus. However, the site
and the mechanism of generation of tinnitus induced by salicylate remains unclear. Here, we …

[PDF][PDF] Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null …

J Ruel, S Emery, R Nouvian, T Bersot, B Amilhon… - The American Journal of …, 2008 - cell.com
Autosomal-dominant sensorineural hearing loss is genetically heterogeneous, with a
phenotype closely resembling presbycusis, the most common sensory defect associated with …

Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea

…, F Casas, C Michel, J Bourien, J Ruel… - Antioxidants & redox …, 2012 - liebertpub.com
Aims: In our aging society, age-related hearing loss (ARHL) or presbycusis is increasingly
important. Here, we study the mechanism of ARHL using the senescence-accelerated mouse …

Dopamine inhibition of auditory nerve activity in the adult mammalian cochlea

J Ruel, R Nouvian, CG d'Aldin, R Pujol… - European Journal of …, 2001 - Wiley Online Library
Efferent feedback systems provide a means for modulating the input to the central nervous
system. The lateral olivocochlear efferents modulate auditory nerve activity via synapses with …

Physiology, pharmacology and plasticity at the inner hair cell synaptic complex

J Ruel, J Wang, G Rebillard, M Eybalin, R Lloyd… - Hearing research, 2007 - Elsevier
This report summarizes recent neuropharmacological data at the IHC afferent/efferent synaptic
complex: the type of Glu receptors and transporter involved and the modulation of this fast …

Salicylate enables cochlear arachidonic-acid-sensitive NMDA receptor responses

J Ruel, C Chabbert, R Nouvian, R Bendris… - Journal of …, 2008 - Soc Neuroscience
Currently, many millions of people treated for various ailments receive high doses of salicylate.
Consequently, understanding the mechanisms by which salicylate induces tinnitus is an …

Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals

J Wang, J Ruel, S Ladrech, C Bonny… - Molecular …, 2007 - ASPET
We tested and characterized the therapeutic value of round window membrane-delivered (RWM)
d-JNKI-1 peptide (Bonny et al., 2001) against sound trauma-induced hearing loss. …

[PDF][PDF] The Nav1. 9 channel is a key determinant of cold pain sensation and cold allodynia

S Lolignier, C Bonnet, C Gaudioso, J Noël, J Ruel… - Cell reports, 2015 - cell.com
Cold-triggered pain is essential to avoid prolonged exposure to harmfully low temperatures.
However, the molecular basis of noxious cold sensing in mammals is still not completely …