Anti‐proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down‐regulation and …

…, N Pommery, N Wattez, C Bailly, JP Hénichart - The …, 2003 - Wiley Online Library
BACKGROUND Anandamide (ANA) is an endogenous lipid which acts as a cannabinoid
receptor ligand and with potent anticarcinogenic activity in several cancer cell types. …

New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy

…, R Houssin, F Durant, JP Hénichart - Journal of medicinal …, 2004 - ACS Publications
The arachidonic acid metabolizing enzymes cyclooxygenase-2 (COX-2) and lipoxygenases
(LOXs) have been found to be implicated in a variety of cancers, including prostate cancer. …

Synthesis of condensed quinolines and quinazolines as DNA ligands

…, JF Goossens, R Houssin, C Bailly, JP Hénichart - Bioorganic & medicinal …, 2004 - Elsevier
Among new condensed quinolines and quinazolines the design of which were inspired by
anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests …

Synthesis and Pharmacological Evaluation of New Pyrazolidine-3,5-diones as AT1 Angiotensin II Receptor Antagonists

…, JF Goossens, R Houssin, JP Hénichart - Journal of medicinal …, 2000 - ACS Publications
On the basis of the structure of the non-peptide receptor antagonist irbesartan, a new series
of AT 1 ligands was designed. In these compounds the central imidazolone nucleus of …

Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: topical therapeutic strategies targeting COX-2 expression and activity

…, C Furman, N Pommery, JP Hénichart - Anti-Cancer Agents in …, 2006 - ingentaconnect.com
The biological role of COX-2, the inducible form of cyclooxygenase, is to convert arachidonic
acid into prostaglandins (PGs) and thromboxanes (TXs). Overexpressed in many tumors, …

The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes

M Noyer, M Gillard, A Matagne, JP Hénichart… - European journal of …, 1995 - Elsevier
Levetiracetam ((S)-α-ethyl-2-oxo-pyrrolidine acetamide, ucb L059) is a novel potential
antiepileptic agent presently in clinical development with unknown mechanism of action. The …

Novel 4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New CB2 Cannabinoid Receptors Agonists:  Synthesis, Pharmacological Properties and Molecular …

…, DM Lambert, P Depreux, JP Hénichart - Journal of medicinal …, 2006 - ACS Publications
Recent data indicated that the CB 2 cannabinoid receptor constitutes an attractive drug target
due to its potential functional role in several physiological and pathological processes. A …

Synthesis, Cytotoxicity, DNA Interaction, and Topoisomerase II Inhibition Properties of Novel Indeno[2,1-c]quinolin-7-one and Indeno[1,2-c]isoquinolin-5,11-dione …

…, R Houssin, C Bailly, JP Hénichart - Journal of medicinal …, 2008 - ACS Publications
Indeno[2,1-c]quinolin-7-ones and 6H-indeno[1,2-c]isoquinolin-5,11-diones, bearing two
cationic aminoalkyl side chains, were synthesized and evaluated for DNA interaction, …

Pharmacomodulations around the 4-Oxo-1,4-dihydroquinoline-3-carboxamides, a Class of Potent CB2-Selective Cannabinoid Receptor Ligands:  Consequences in …

…, R Millet, JH Poupaert, JP Hénichart… - Journal of medicinal …, 2007 - ACS Publications
CB 2 receptor selective ligands are becoming increasingly attractive drugs due to the potential
role of this receptor in several physiopathological processes. Thus, the development of …

Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate …

…, E Moore, N Moniaux, JP Hénichart… - … journal of cancer, 2006 - Wiley Online Library
Although the blockade of the hedgehog cascade by using cyclopamine has been reported
to inhibit the growth of some cancer cell types, few studies on the mechanism by which this …