Differential effects of α‐, β‐and γ‐cyclodextrins on human erythrocytes
…, K Uekama, K Fukunaga, J Pitha - European journal of …, 1989 - Wiley Online Library
α‐, β‐ and γ‐cyclodextrins are cyclic hexamers, heptamers, and octamers of glucose,
respectively, and thus are hydrophilic; nevertheless, they have the ability to solubilize lipids …
respectively, and thus are hydrophilic; nevertheless, they have the ability to solubilize lipids …
Hydroxypropyl-β-cyclodextrin: preparation and characterization; effects on solubility of drugs
J Pitha, J Milecki, H Fales, L Pannell… - international Journal of …, 1986 - Elsevier
Conditions for condensation of β-cyclodextrin with propylene oxide were found which give
preparations of hydroxypropyl-β-cyclodextrin with a narrow and symmetrical distribution of the …
preparations of hydroxypropyl-β-cyclodextrin with a narrow and symmetrical distribution of the …
[HTML][HTML] Intracellular trafficking of cholesterol monitored with a cyclodextrin
EB Neufeld, AM Cooney, J Pitha… - Journal of Biological …, 1996 - ASBMB
The sterol binding agent 2-hydroxypropyl-β-cyclodextrin is shown to be a convenient and
useful experimental tool to probe intracellular pathways of cholesterol transport. Biochemical …
useful experimental tool to probe intracellular pathways of cholesterol transport. Biochemical …
Drug solubilizers to aid pharmacologists: amorphous cyclodextrin derivatives
J Pitha, T Irie, PB Sklar, JS Nye - Life sciences, 1988 - Elsevier
Conversion of crystalline α-, β-, or γ-cyclodextrins into amorphous mixtures of water soluble
derivatives yields non-toxic solubilizers which dissolve drugs through the formation of …
derivatives yields non-toxic solubilizers which dissolve drugs through the formation of …
Hydroxypropylcyclodextrins in parenteral use. I: Lipid dissolution and effects on lipid transfers in vitro
T Irie, K Fukunaga, J Pitha - Journal of pharmaceutical sciences, 1992 - Elsevier
Hydroxypropyl ethers of cyclodextrins form water‐soluble inclusion complexes with lipids. Of
the three hydroxypropylcyclodextrins examined, hydroxypropyl‐α‐cyclodextrin had limited …
the three hydroxypropylcyclodextrins examined, hydroxypropyl‐α‐cyclodextrin had limited …
Amorphous water-soluble derivatives of cyclodextrins: nontoxic dissolution enhancing excipients
J Pitha, J Pitha - Journal of pharmaceutical sciences, 1985 - Elsevier
Dissolution properties of drugs may be improved by their conversion to an amorphous state
or by complexation with cyclodextrins. The present report describes the preparation of …
or by complexation with cyclodextrins. The present report describes the preparation of …
Distribution of substituents in 2-hydroxypropyl ethers of cyclomaltoheptaose
J Pitha, CT Rao, B Lindberg, P Seffers - Carbohydrate Research, 1990 - Elsevier
The distribution of substituents in 2-hydroxypropyl ethers of cyclomaltoheptaose, prepared
by alkylation of the carbohydrate with propylene oxide in aqueous sodium hydroxide, was …
by alkylation of the carbohydrate with propylene oxide in aqueous sodium hydroxide, was …
(S)-2-Hydroxyprophyl-β-cyclodextrin, a new chiral stationary phase for reversed-phase liquid chromatography
…, SC Chang, DW Armstrong, J Pitha - Journal of Chromatography …, 1990 - Elsevier
(S)-2- and (R,S)-2-hydroxypropyl-β-cyclodextrin have been bonded to silica gel and evaluated
as stationary phases for reversed-phase liquid chromatography. Stationary phases also …
as stationary phases for reversed-phase liquid chromatography. Stationary phases also …
Polar-liquid, derivatized cyclodextrin stationary phases for the capillary gas chromatography separation of enantiomers
DW Armstrong, W Li, CD Chang, J Pitha - Analytical chemistry, 1990 - ACS Publications
A new class of hydrophilic, relatively polar Hquld, cyclodextrin (CD) derivatives have beenused
as highly selective chiral stationary phases (CSPs) for capillary gas chromatography (GC)…
as highly selective chiral stationary phases (CSPs) for capillary gas chromatography (GC)…
Effects of ethanol on formation of inclusion complexes of hydroxypropylcyclodextrins with testosterone or with methyl orange
J Pitha, T Hoshino - International journal of pharmaceutics, 1992 - Elsevier
Gradual additions of ethanol decreased and eventually abolished the formation of inclusion
complexes of testosterone with hydroxypropylcyclodextrins in aqueous solutions. With …
complexes of testosterone with hydroxypropylcyclodextrins in aqueous solutions. With …