Novel classes of heterocyclic compounds as adenosine antagonists were developed based
on a template approach. Structure−affinity relationships revealed insights for extended …

Isoquinoline and quinazoline urea derivatives were found to bind to human adenosine A 3
receptors. Series of N-phenyl-N‘-quinazolin-4-ylurea derivatives and N-phenyl-N‘-isoquinolin-…

In recent years, the technical possibilities of educational technologies regarding online peer
feedback have developed rapidly. However, the impact of online peer feedback activities …

Interactive teaching with larger groups of students can be a challenge, but the use of mobile
electronic devices by students (smartphones, tablets, laptops) can be used to improve …

Allosteric modulators of A 1 and A 2A adenosine receptors have been described; however,
for the A 3 adenosine receptor, neither an allosteric site nor a compound with allosteric …

The 5-HT 3 receptor, a pentameric ligand-gated ion channel (pLGIC), is an important
therapeutic target. During a recent fragment screen, 6-chloro-N-methyl-2-(4-methyl-1,4-diazepan-1-…

A series of 3-(2-pyridinyl)isoquinoline derivatives was synthesized as potential antagonists
for the human adenosine A 3 receptor by substitution of the 1-position. The compounds were …

1-Substituted 3-(2-pyridinyl)isoquinolines have been shown to form a novel class of adenosine
A 3 receptor ligands. In the present study further investigations of this new lead and the …

A fragment library was screened against the G protein-coupled histamine H 4 receptor (H 4
R) and the ligand-gated ion channel serotonin 5-HT 3A (5-HT 3A R). Interestingly, significant …

SPR (Surface Plasmon Resonance) biosensor instruments are more and more equipped to
sensitively measure the binding characteristics of small molecules to their target. Via SPR …