Selection‐dominant and nonaccessible epitopes on cell‐surface receptors revealed by cell‐panning with a large phage antibody library

…, MMAL Pelsers, MJMM Rousch, J Coote… - European journal of …, 1999 - Wiley Online Library
To generate antibodies to defined cell‐surface antigens, we used a large phage antibody
fragment library to select on cell transfectants expressing one of three chosen receptors. First, …

Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor

TM Palmer, CA Harris, J Coote, GL Stiles - Molecular Pharmacology, 1997 - ASPET
The A 3 adenosine receptor (A 3 AR) contributes to several cardiovascular effects of adenosine,
including antihypertensive and cardioprotective effects. Although several studies have …

Somatostatin displayed on filamentous phage as a receptor‐specific agonist

M Rousch, JT Lutgerink, J Coote… - British journal of …, 1998 - Wiley Online Library
1 In search of methods to identify bio‐active ligands specific for G protein‐coupled receptors
with seven transmembrane spanning regions, we have developed a filamentous phage‐…

Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone:  A Potent, Orally Bioavailable Human CB1/CB2 Dual Agonist with Antihyperalgesic Properties and …

…, A Groarke, TW Hart, W Huber, IF James… - Journal of medicinal …, 2007 - ACS Publications
Selective activation of peripheral cannabinoid CB 1 receptors has the potential to become a
valuable therapy for chronic pain conditions as long as central nervous system effects are …

The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular …

…, L Volksone, T Zeyen, I Filatori, J James… - Journal of …, 2009 - journals.lww.com
Purpose This study compared the intraocular pressure (IOP)-lowering efficacy of 2 fixed
combination products, brinzolamide 1%/timolol 0.5% suspension (Azarga, Brinz/Tim) and …

Stimulation of the secretion of plasminogen activator from activated murine macrophages by microtubule disrupting agents and deuterium oxide

HP Humphray, JE Coote, IF Skidmore - Biochemical Pharmacology, 1980 - Elsevier
Murine peritoneal macrophages activated in vivo with thioglycollate broth secrete plasminogen
activator and other neutral proteinases. The secretion of plasminogen activator by these …

[BOOK][B] The Eclectic Odyssey of Atlee B. Ayres, Architect

RJ Coote - 2001 - books.google.com
James Coote focuses on Ayres's earlytwentieth-century residential architecture and the sources
from which he drew inspiration. During the three decades CooteCoote studies in detail …

[BOOK][B] The welfare of citizens: Developing new social rights

A Coote - 1992 - books.google.com
I am indebted to all the authors for their invaluable, and largely unrewarded contributions; to
Raymond Plant for inspiring this project in the first place, and to Tessa Harding for her moral …

Immunochemical detection of photoaffinity‐labelled capsaicin‐binding proteins from sensory neurons

…, C Walpole, IF James, A Dray, PR Coote - FEBS letters, 1990 - Wiley Online Library
Capsaicin is a plant neurotoxin which depolarises a subset of mammalian sensory neurons.
A photoaffinity probe (4‐azidophenylpropionamide) with capsaicin‐like agonist activity (EC …

[HTML][HTML] Dynamic characterisation of fibre-optic temperature sensors for physiological monitoring

JM Coote, R Torii, AE Desjardins - Sensors, 2020 - mdpi.com
Fast, miniature temperature sensors are required for various biomedical applications. Fibre-optics
are particularly suited to minimally invasive procedures, and many types of fibre-optic …