A family of drug transporters: the multidrug resistance-associated proteins
The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …
members. The ability of several of these membrane proteins to transport a wide range of …
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
J Wijnholds, CAAM Mol… - Proceedings of the …, 2000 - National Acad Sciences
Two prominent members of the ATP-binding cassette superfamily of transmembrane
proteins, multidrug resistance 1 (MDR1) P-glycoprotein and multidrug resistance protein 1 (MRP1), …
proteins, multidrug resistance 1 (MDR1) P-glycoprotein and multidrug resistance protein 1 (MRP1), …
Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure
…, P Rashbass, A Le Bivic, J Wijnholds - Journal of cell …, 2004 - journals.biologists.com
… , Anna Malysheva, Jan Meuleman, Inge Versteeg, Christiaan Levelt, Jan Klooster, Sylvia
Geiger, Mathias W. Seeliger, Penny Rashbass, Andre Le Bivic, Jan Wijnholds; Crumbs …
Geiger, Mathias W. Seeliger, Penny Rashbass, Andre Le Bivic, Jan Wijnholds; Crumbs …
[HTML][HTML] The multidrug resistance protein family
The human multidrug resistance protein (MRP) family contains at least six members: MRP1,
the godfather of the family and well known as the multidrug resistance protein, and five …
the godfather of the family and well known as the multidrug resistance protein, and five …
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
…, A Kuil, M de Haas, J Wijnholds… - Proceedings of the …, 2003 - National Acad Sciences
Prostaglandins are involved in a wide variety of physiological and pathophysiological
processes, but the mechanism of prostaglandin release from cells is not completely understood. …
processes, but the mechanism of prostaglandin release from cells is not completely understood. …
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5
…, N Zelcer, M De Haas, L Van Deemter, J Wijnholds… - Molecular …, 2003 - ASPET
The human multidrug resistance proteins MRP4 and MRP5 are organic anion transporters
that have the unusual ability to transport cyclic nucleotides and some nucleoside …
that have the unusual ability to transport cyclic nucleotides and some nucleoside …
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
J Wijnholds, R Evers, MR van Leusden, CAAM Mol… - Nature medicine, 1997 - nature.com
The multidrug resistance-associated protein (MRP) mediates the cellular excretion of many
drugs, glutathione S-conjugates (GS-X) of lipophilic xenobiotics and endogenous cysteinyl …
drugs, glutathione S-conjugates (GS-X) of lipophilic xenobiotics and endogenous cysteinyl …
[HTML][HTML] Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
J Wijnholds, ECM de Lange… - The Journal of …, 2000 - Am Soc Clin Investig
Multidrug resistance protein 1 (MRP1) is a transporter protein that helps to protect normal
cells and tumor cells against the influx of certain xenobiotics. We previously showed that Mrp1 …
cells and tumor cells against the influx of certain xenobiotics. We previously showed that Mrp1 …
The Mouse Bcrp1/Mxr/Abcp Gene: Amplification and Overexpression in Cell Lines Selected for Resistance to Topotecan, Mitoxantrone, or Doxorubicin
JD Allen, RF Brinkhuis, J Wijnholds, AH Schinkel - Cancer research, 1999 - AACR
Mouse fibroblast cell lines lacking functional Mdr1a, Mdr1b, and Mrp1 genes were selected
for resistance to topotecan, mitoxantrone, or doxorubicin. Each of the resulting drug-resistant …
for resistance to topotecan, mitoxantrone, or doxorubicin. Each of the resulting drug-resistant …
[HTML][HTML] Characterization of the MRP4-and MRP5-mediated transport of cyclic nucleotides from intact cells
…, G Reid, JH Beijnen, J Wijnholds… - Journal of Biological …, 2003 - ASBMB
Cyclic nucleotides are known to be effluxed from cultured cells or isolated tissues. Two recently
described members of the multidrug resistance protein family, MRP4 and MRP5, might …
described members of the multidrug resistance protein family, MRP4 and MRP5, might …