Cholesterol is a key component of cell membranes with a proven modulatory role on the
function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal …

Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are
critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of …

G-protein-coupled receptors (GPCRs) are involved in numerous physiological processes and
are the most frequent targets of approved drugs. The explosion in the number of new three-…

Computer simulations are giving way to more complex and accurate studies of biological
membranes by molecular dynamics (MD) simulations. The analysis of MD trajectories …

Membrane proteins mediate processes that are fundamental for the flourishing of biological
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …

G-protein coupled receptors, the largest family of proteins in the human genome, are involved
in many complex signal transduction pathways, typically activated by orthosteric ligand …

β‐arrestins (βarrs) are key regulators of G protein‐coupled receptor ( GPCR ) signaling and
trafficking, and their knockdown typically leads to a decrease in agonist‐induced ERK 1/2 …

Membrane levels of docosahexaenoic acid (DHA), an essential omega-3 polyunsaturated
fatty acid (ω-3 PUFA), are decreased in common neuropsychiatric disorders. DHA modulates …

β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and
desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin …

GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third
of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage …