International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

…, S O'Rahilly, CNA Palmer, J Plutzky, JK Reddy… - Pharmacological …, 2006 - ASPET
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree of …

Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation

JK Reddy, M Sambasiva Rao - American Journal of …, 2006 - journals.physiology.org
Fatty liver disease (FLD), whether it is alcoholic FLD (AFLD) or nonalcoholic FLD (NAFLD),
encompasses a morphological spectrum consisting of hepatic steatosis (fatty liver) and …

PEROXISOMAL β-OXIDATION AND PEROXISOME PROLIFERATOR–ACTIVATED RECEPTOR α: An Adaptive Metabolic System

JK Reddy, T Hashimoto - Annual review of nutrition, 2001 - annualreviews.org
▪ Abstract β-Oxidation occurs in both mitochondria and peroxisomes. Mitochondria catalyze
the β-oxidation of the bulk of short-, medium-, and long-chain fatty acids derived from diet, …

Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.

JV Schmidt, GH Su, JK Reddy… - Proceedings of the …, 1996 - National Acad Sciences
The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic
response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-…

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two …

…, D Noya, MS Rao, JK Reddy - Proceedings of the …, 1995 - National Acad Sciences
To gain insight into the regulation of expression of peroxisome proliferator-activated receptor
(PPAR) isoforms, we have determined the structural organization of the mouse PPAR …

[HTML][HTML] Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) …

…, AV Yeldandi, MS Rao, FJ Gonzalez, JK Reddy - Journal of Biological …, 2003 - ASBMB
Peroxisome proliferator activated-receptor (PPAR) isoforms, α and γ, function as important
coregulators of energy (lipid) homeostasis. PPARα regulates fatty acid oxidation primarily in …

[HTML][HTML] Defect in peroxisome proliferator-activated receptor α-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting

…, WS Cook, C Qi, AV Yeldandi, JK Reddy… - Journal of Biological …, 2000 - ASBMB
Fasting causes lipolysis in adipose tissue leading to the release of large quantities of free
fatty acids into circulation that reach the liver where they are metabolized to generate ketone …

Application of comparative functional genomics to identify best-fit mouse models to study human cancer

…, IS Chu, A Mikaelyan, DF Calvisi, J Heo, JK Reddy… - Nature …, 2004 - nature.com
Genetically modified mice have been extensively used for analyzing the molecular events that
occur during tumor development. In many, if not all, cases, however, it is uncertain to what …

Peroxisomal lipid metabolism

JK Reddy, GP Mannaerts - Annual review of nutrition, 1994 - annualreviews.org
… interactions within the peroxisome proReddy JK. 1989. In vivo distribution of … Zhu Y,
Alvares K, Huang Q, Rao MS, Characteristics and subcellular localiza… Reddy lK. Cloning …

[HTML][HTML] Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

…, K Alvares, Q Huang, MS Rao, JK Reddy - Journal of Biological …, 1993 - Elsevier
Peroxisome proliferators are postulated to elicit predictable pleiotropic responses in the liver
by activating a peroxisome proliferator-activated receptor (PPAR). PPARs from mouse liver (…