User profiles for Jane Kuk

Jane Kuk

University of Illinois at Chicago
Verified email at uic.edu
Cited by 1911

Crystal structure of Pseudomonas aeruginosa bacteriophytochrome: Photoconversion and signal transduction

X Yang, J Kuk, K Moffat - Proceedings of the National …, 2008 - National Acad Sciences
Phytochromes are red-light photoreceptors that regulate light responses in plants, fungi,
and bacteria via reversible photoconversion between red (Pr) and far-red (Pfr) light-absorbing …

A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative

T Matsumoto, M Nakane, JS Pollock, JE Kuk… - Neuroscience …, 1993 - Elsevier
In histochemical studies using fixed brain tissue, NADPH-diaphorase has been found to be
colocalized with soluble nitric oxide synthase. In the present study, using fresh tissues from …

Crystal structure of the chromophore binding domain of an unusual bacteriophytochrome, RpBphP3, reveals residues that modulate photoconversion

X Yang, EA Stojković, J Kuk… - Proceedings of the …, 2007 - National Acad Sciences
Bacteriophytochromes RpBphP2 and RpBphP3 from the photosynthetic bacterium
Rhodopseudomonas palustris work in tandem to modulate synthesis of the light-harvesting complex …

Temperature-scan cryocrystallography reveals reaction intermediates in bacteriophytochrome

X Yang, Z Ren, J Kuk, K Moffat - Nature, 2011 - nature.com
Light is a fundamental signal that regulates important physiological processes such as
development and circadian rhythm in living organisms. Phytochromes form a major family of …

Conformational differences between the Pfr and Pr states in Pseudomonas aeruginosa bacteriophytochrome

X Yang, J Kuk, K Moffat - Proceedings of the National …, 2009 - National Acad Sciences
Phytochromes are red-light photoreceptors that regulate light responses in plants, fungi,
and bacteria by means of reversible photoconversion between red (Pr) and far-red (Pfr) light-…

Novel potent and selective inhibitors of inducible nitric oxide synthase.

M Nakane, V Klinghofer, JE Kuk, JL Donnelly… - Molecular …, 1995 - ASPET
We have identified two novel potent and selective inhibitors of inducible nitric oxide synthase,
S-ethylisothiourea and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine. Ki values of 14.7 …

[PDF][PDF] Light signaling mechanism of two tandem bacteriophytochromes

X Yang, EA Stojković, WB Ozarowski, J Kuk… - Structure, 2015 - cell.com
RpBphP2 and RpBphP3, two tandem bacteriophytochromes from the photosynthetic
bacterium Rhodopseudomonas palustris, share high sequence identity but exhibit distinct …

Light-induced protein structural dynamics in bacteriophytochrome revealed by time-resolved x-ray solution scattering

…, SR Yun, C Kim, Z Ren, I Kumarapperuma, J Kuk… - Science …, 2022 - science.org
Bacteriophytochromes (BphPs) are photoreceptors that regulate a wide range of biological
mechanisms via red light–absorbing (Pr)–to–far-red light–absorbing (Pfr) reversible …

trans-Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2, 5-dihydro-9-hydroxy-10-methoxy-2, 2, 4-trimethyl-5-(1 …

CW Lin, M Nakane, M Stashko, D Falls, J Kuk… - Molecular …, 2002 - ASPET
Glucocorticoids are potent anti-inflammatory and immunosuppressant agents. However,
they also produce serious side effects that limit their usage. It has been proposed that anti-…

[PDF][PDF] The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat.

WR Tracey, M Nakane, J Kuk, G Budzik… - … of Pharmacology and …, 1995 - Citeseer
Nitric oxide(NO) is a biological mediator that, when produced by the type II (inducible) nitric
oxide synthase(NOS), has been implicated in the pathophysiology of inflammatory diseases. …