Nicotinic modulation of glutamate and GABA synaptic transmission in hippocampal neurons
KA Radcliffe, JL Fisher, R Gray… - Annals of the New York …, 1999 - Wiley Online Library
Although the hippocampus expresses nicotinic acetylcholine receptors (nAChRs) and
receives cholinergic innervation, the functional roles of these receptors are not completely …
receives cholinergic innervation, the functional roles of these receptors are not completely …
The anti-convulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator
JL Fisher - Neuropharmacology, 2009 - Elsevier
Stiripentol (STP) has been used as co-therapy for treatment of epilepsy for many years. Its
mechanism of action has long been considered to be indirect, as it inhibits the enzymes …
mechanism of action has long been considered to be indirect, as it inhibits the enzymes …
Single channel properties of recombinant GABAA receptors containing γ2 or δ subtypes expressed with α1 and β3 subtypes in mouse L929 Cells
JL Fisher, RL Macdonald - The Journal of physiology, 1997 - Wiley Online Library
1 To determine their contributions to GABA A receptor (GABAR) channel properties, rat γ2L
and δ subunits were acutely co‐expressed with α1 and β3 subtypes in mouse L929 …
and δ subunits were acutely co‐expressed with α1 and β3 subtypes in mouse L929 …
Fluoxetine increases GABAA receptor activity through a novel modulatory site
RT Robinson, BC Drafts, JL Fisher - Journal of Pharmacology and …, 2003 - ASPET
Fluoxetine is a selective serotonin reuptake inhibitor used widely in the treatment of
depression. In contrast to the proconvulsant effect of many antidepressants, fluoxetine has …
depression. In contrast to the proconvulsant effect of many antidepressants, fluoxetine has …
The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors
M Alexeev, DK Grosenbaugh, DD Mott, JL Fisher - Neuropharmacology, 2012 - Elsevier
The National Center for Complementary and Alternative Medicine (NCCAM) estimates that
nearly 40% of adults in the United States use alternative medicines, often in the form of an …
nearly 40% of adults in the United States use alternative medicines, often in the form of an …
Novel benzodiazepine-like ligands with various anxiolytic, antidepressant, or pro-cognitive profiles
…, NM Zahn, LA Arnold, P Scholze, JL Fisher… - Molecular …, 2019 - karger.com
Altered gamma-aminobutyric acid (GABA) function is consistently reported in psychiatric
disorders, normal aging, and neurodegenerative disorders and reduced function of GABA …
disorders, normal aging, and neurodegenerative disorders and reduced function of GABA …
The effects of stiripentol on GABAA receptors
JL Fisher - Epilepsia, 2011 - Wiley Online Library
The anticonvulsant stiripentol (Diacomit™) has been shown to have a positive impact on
control of seizures for many patients with Dravet syndrome. As with most antiepileptic drugs, …
control of seizures for many patients with Dravet syndrome. As with most antiepileptic drugs, …
Spontaneous and γ-aminobutyric acid (GABA)-activated GABAA receptor channels formed by ε subunit-containing isoforms
TR Neelands, JL Fisher, M Bianchi… - Molecular …, 1999 - ASPET
A new γ-aminobutyric acid (GABA) A receptor (GABAR) subunit class, ε, has recently been
cloned and shown to form functional channels when coexpressed with both α and β subunits. …
cloned and shown to form functional channels when coexpressed with both α and β subunits. …
A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung
…, R Jahan, ML Guthrie, OB Yu, JL Fisher… - Molecular …, 2018 - ACS Publications
We describe lead compound MIDD0301 for the oral treatment of asthma based on previously
developed positive allosteric α 5 β 3 γ 2 selective GABA A receptor (GABA A R) ligands. …
developed positive allosteric α 5 β 3 γ 2 selective GABA A receptor (GABA A R) ligands. …
Antinociceptive Effects of a Novel α2/α3-Subtype Selective GABAA Receptor Positive Allosteric Modulator
LA Lewter, JL Fisher, JN Siemian… - ACS chemical …, 2017 - ACS Publications
Pain remains a challenging clinical condition and spinal GABA A receptors are crucial
modulators of pain processing. α2/α3-subtype GABA A receptors mediate the analgesic actions of …
modulators of pain processing. α2/α3-subtype GABA A receptors mediate the analgesic actions of …