Exposure of rats to the pesticide and complex I inhibitor rotenone reproduces features of
Parkinson's disease, including selective nigrostriatal dopaminergic degeneration and α-…

… The present address of Jason R. Richardson is the Department of Environmental and
Occupational Medicine Robert Wood Johnson Medical School and the Environmental and …

The vesicular monoamine transporter 2 (VMAT2; SLC18A2) is responsible for packaging
dopamine into vesicles for subsequent release and has been suggested to serve a …

Pesticides are unique environmental contaminants that are specifically introduced into the
environment to control pests, often by killing them. Although pesticide application serves …

Paraquat, MPTP, and rotenone reproduce features of Parkinson's disease (PD) in experimental
animals. The exact mechanisms by which these compounds damage the dopamine …

Importance The causes of late-onset Alzheimer disease (AD) are not yet understood but
likely include a combination of genetic, environmental, and lifestyle factors. Limited …

Exposure to pesticides has been suggested to increase the risk of Parkinson's disease (PD),
but the mechanisms responsible for this association are not clear. Here, we report that …

Pyrethroid insecticides are one of the most commonly used residential and agricultural
insecticides. Based on the increased use of pyrethroids and recent studies showing that pregnant …

Background Pyrethroid pesticides cause abnormalities in the dopamine system and produce
an ADHD phenotype in animal models, with effects accentuated in males versus females. …

Exposure to the pyrethroid pesticide deltamethrin has been demonstrated to cause
apoptosis both in vitro and in vivo. However, the molecular pathways leading to deltamethrin-induced …