Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II
…, J Couprie, J Pierre, A Jacquemin-Sablon, JM Saucier… - Cancer research, 1989 - AACR
Tyrosine phosphorylation plays a crucial role in cell proliferation and cell transformation
which suggests that tyrosine kinase-specific inhibitors might be used as anticancer agents. …
which suggests that tyrosine kinase-specific inhibitors might be used as anticancer agents. …
Stimulation of topoisomerase II-mediated DNA cleavage by ellipticine derivatives: structure-activity relationship.
…, B René, M Charra, C Paoletti, JM Saucier - Molecular pharmacology, 1992 - ASPET
Ellipticines are aromatic compounds that intercalate between DNA base pairs and display
significant antitumor activity. The cytotoxicity of these compounds is mediated by DNA …
significant antitumor activity. The cytotoxicity of these compounds is mediated by DNA …
Intoplicine (RP 60475) and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities
…, AK Larsen, MC Bissery, L Grondard, JM Saucier… - Cancer research, 1993 - AACR
Intoplicine (RP 60475, NSC 645008) is an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole
series which is now being tested in clinical trials. Intoplicine strongly binds DNA (K …
series which is now being tested in clinical trials. Intoplicine strongly binds DNA (K …
Angular Alteration of the DNA Helix by E. coli RNA Polymerase
JM SAUCIER, JC WANG - Nature New Biology, 1972 - nature.com
IT has been a source of speculation whether the reading of the genetic code of DNA by RNA
polymerase involves the disruption of the DNA helix. While circuitous evidence favouring …
polymerase involves the disruption of the DNA helix. While circuitous evidence favouring …
S16020–2, a new highly cytotoxic antitumor olivacine derivative: DNA interaction and DNA topoisomerase II inhibition
…, G Atassi, A Jacquemin-Sablon, JM Saucier - Molecular …, 1998 - ASPET
S16020–2 (NSC-659687) is a new olivacine derivative that is highly cytotoxic in vitro and
displays remarkable antitumor activity against various experimental tumors, especially some …
displays remarkable antitumor activity against various experimental tumors, especially some …
Physicochemical studies on interactions between DNA and RNA polymerase. Unwinding of the DNA helix by Escherichia coli RNA polymerase
JC Wang, JH Jacobsen, JM Saucier - Nucleic Acids Research, 1977 - academic.oup.com
In a medium containing 10 mM Tris, pH 8, 10 mM Mg ++ ,50 mM K + and 10 mM NH4, the
binding of an E.coli RNA polymerase holoenzyme unwinds the DNA helix by about 240 at 37C. …
binding of an E.coli RNA polymerase holoenzyme unwinds the DNA helix by about 240 at 37C. …
Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative
…, B Rene, M Le Bret, C Paoletti, JM Saucier - Nucleic acids …, 1991 - academic.oup.com
Various antitumor drugs stabilize DNA topoisomerase II-DNA transient covalent complexes.
The complexes distribution along pBR322 DNA was shown previously to depend upon the …
The complexes distribution along pBR322 DNA was shown previously to depend upon the …
A carboline derivative as a novel mammalian DNA topoisomerase II targeting agent
F Pognan, JM Saucier, C Paoletti, L Kaczmarek… - Biochemical …, 1992 - Elsevier
The DNA intercalating, ellipticine analog drug, 5,11-dimethyl-5H-indolo[2,3-b]quinoline, is
able to stabilize in vitro the topoisomerase II-DNA cleavable complex and to induce DNA …
able to stabilize in vitro the topoisomerase II-DNA cleavable complex and to induce DNA …
Genistein resistance in human leukaemic CCRF-CEM cells: selection of a diploid cell line with reduced DNA topoisomerase II β isoform
…, C Luccioni, J Beaumatin, JM Saucier… - Biochemical …, 1995 - Elsevier
Genistein, an isoflavonoid derivative initially described as an in vitro protein tyrosine kinase
inhibitor, also inhibits mammalian DNA topoisomerase II both in vitro and in vivo. From a …
inhibitor, also inhibits mammalian DNA topoisomerase II both in vitro and in vivo. From a …
Reduced DNA topoisomerase II activity and drug-stimulated DNA cleavage in 9-hydroxyellipticine resistant cells
JY Charcosset, JM Saucier… - Biochemical …, 1988 - Elsevier
We have isolated a Chinese hamster lung cell line resistant to 9-hydroxyellipticine (DC-3F/9-OH-E)
which is also cross-resistant to topoisomerase II inhibitors such as amsacrine and …
which is also cross-resistant to topoisomerase II inhibitors such as amsacrine and …