Optimal protein function often depends on co-operative interactions between amino acid
residues distant in the protein primary sequence yet spatially near one another following …

Angiogenesis plays a central role in the growth and metastasis of cancers. Strategies aimed
at interfering with tumor blood supply offer promise for new cancer therapies. Vitaxin (an anti…

A protein engineering strategy based on efficient and focused mutagenesis implemented by
codon-based mutagenesis was developed. Vitaxin, a humanized version of the …

We describe here the selection of ultra-potent anti-respiratory syncytial virus (RSV) antibodies
for preventing RSV infection. A large number of antibody variants derived from Synagis ® (…

Directed evolution is a broadly applicable technology platform that is ideally suited to address
the need for protein optimization and to fully exploit the therapeutic potential of biologics. …

The location of CTP:phosphocholine cytidylyltransferase in Chinese hamster ovary (CHO)
cells made deficient in phosphatidylcholine was determined by immunofluorescence …

We previously found that injection of a cocaine hydrolase (CocE) engineered from human
butyrylcholinesterase will transiently accelerate cocaine metabolism in rats while reducing …

Therapeutic Abs directed toward TNF-α display significant immunogenicity in humans,
frequently leading to lower serum concentrations of the Ab that are associated with lower …

An assay for the rapid identification and cloning of antibody fragments (Fabs) reactive with
cell surface antigens was established and used to identify Fabs selectively reactive with tumor …

Human lymphocytes secreting tumor cell-specific IgM antibodies were enriched in vitro
following the stimulation of allogeneic human splenocytes from nontumor-bearing donors with …