Millions of people worldwide with incurable end-stage lung disease die because of inadequate
treatment options and limited availability of donor organs for lung transplantation 1 . …

Asthma, a common disorder associated with airway inflammation and hyperresponsiveness,
remains a significant clinical burden in need of novel therapeutic strategies. Patients are …

Viral infection often causes severe damage to the lungs, leading to the appearance of
ectopic basal cells (EBCs) and tuft cells in the lung parenchyma. Thus far, the roles of these …

Objective To determine the presence of calcium activated chloride channels anoctamin 1 (ANO1)
and 2 (ANO2) in human and murine uterine smooth muscle (MUSM) and evaluate the …

Background: Perioperative bronchospasm refractory to β agonists continues to challenge
anesthesiologists and intensivists. The TMEM16A calcium-activated chloride channel …

Emerging evidence indicates that hypnotic anesthetics affect immune function. Many anesthetics
potentiate γ-aminobutyric acid A receptor (GABA A R) activation, and these receptors …

We have reported previously that interleukin-1 and tumor necrosis factor (TNF)-α increase
expression and function of adenosine A 2A receptors (A 2A Rs), although the increased …

Airway smooth muscle hyperresponsiveness is a key component in the pathophysiology of
asthma. Although calcium-activated chloride channel (CaCC) flux has been described in …

TMEM16A (anoctamin 1) is an important calcium-activated chloride channel in airway
smooth muscle (ASM). We have previously shown that TMEM16A antagonists such as …

Vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are key
angiogenic stimulators during normal development and wound healing, as well as in a variety of …