User profiles for Jiejun Wu

jiejun wu

Johnson and Johnson
Verified email at its.jnj.com
Cited by 2597

[HTML][HTML] Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81

C Liu, J Wu, J Zhu, C Kuei, J Yu, J Shelton… - Journal of Biological …, 2009 - ASBMB
Lactic acid is a well known metabolic by-product of intense exercise, particularly under anaerobic
conditions. Lactate is also a key source of energy and an important metabolic substrate…

Oxysterols direct B-cell migration through EBI2

C Liu, XV Yang, J Wu, C Kuei, NS Mani, L Zhang, J Yu… - Nature, 2011 - nature.com
EBI2 (also called GPR183) is an orphan G-protein-coupled receptor that is highly expressed
in spleen and upregulated upon Epstein–Barr-virus infection 1 . Recent studies indicated …

Damping and sound absorption properties of particle reinforced Al matrix composite foams

W Jiejun, L Chenggong, W Dianbin… - Composites Science and …, 2003 - Elsevier
In this paper, the damping and sound absorption properties of A356/xSiC p composite foams
have been studied (x expresses SiC vol.%). The results show that the loss factor β of A356/…

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

P Soroosh, J Wu, X Xue, J Song… - Proceedings of the …, 2014 - National Acad Sciences
The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating
IL-17–producing CD4 + Th17 T cells, which are essential in host defense and may play …

[HTML][HTML] INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

…, C Kuei, S Sutton, J Chen, P Bonaventure, J Wu… - Journal of Biological …, 2005 - ASBMB
Insulin-like peptide 5 (INSL5) is a peptide that belongs to the relaxin/insulin family, and its
receptor has not been identified. In this report, we demonstrate that INSL5 is a specific agonist …

Modulation of DNA methylation by a sesquiterpene lactone parthenolide

Z Liu, S Liu, Z Xie, RE Pavlovicz, J Wu, P Chen… - … of Pharmacology and …, 2009 - ASPET
Hypermethylation of 5′-cytosine-guanosine islands of tumor suppressor genes resulting in
their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA …

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

…, R De Cabo, E Rogaev, J Egan, J Wu… - Science translational …, 2018 - science.org
Aging in humans is associated with increased hyperglycemia and insulin resistance (collectively
termed IR) and dysregulation of the immune system. However, the causative factors …

Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis

…, NE Moore, GR Aleman Muench, J Wu… - Nature …, 2020 - nature.com
The gut microbiome is a malleable microbial community that can remodel in response to
various factors, including diet, and contribute to the development of several chronic diseases, …

[HTML][HTML] R3 (BΔ23–27) R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: In vitro and in vivo characterization

…, J Shelton, J Zhu, D Nepomuceno, J Wu… - Journal of Biological …, 2007 - ASBMB
Both relaxin-3 and its receptor (GPCR135) are expressed predominantly in brain regions
known to play important roles in processing sensory signals. Recent studies have shown that …

3, 5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes

…, MA Connelly, G Lee, N Carruthers, J Wu… - … of Pharmacology and …, 2012 - ASPET
Niacin raises high-density lipoprotein and lowers low-density lipoprotein through the activation
of the β-hydroxybutyrate receptor hydroxycarboxylic acid 2 (HCA2) (aka GPR109a) but …