Therapeutic application of GPR119 ligands in metabolic disorders

JW Yang, HS Kim, YW Choi, YM Kim… - Diabetes, Obesity and …, 2018 - Wiley Online Library
GPR119 belongs to the G protein‐coupled receptor family and exhibits dual modes of
action upon ligand‐dependent activation: pancreatic secretion of insulin in a glucose‐dependent …

Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells

SK Kim, JW Yang, MR Kim, SH Roh, HG Kim… - Free Radical Biology …, 2008 - Elsevier
Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem in breast cancer
patients. In this study, we found that the expressions of anti-oxidant proteins (γ-…

Impregnation of vancomycin, gentamicin, and cefotaxime in a cement spacer for two-stage cementless reconstruction in infected total hip arthroplasty

KH Koo, JW Yang, SH Cho, HR Song, HB Park… - The Journal of …, 2001 - Elsevier
Twenty-two patients with infected total hip arthroplasty were treated with 2-stage arthroplasty,
using a cement spacer impregnated with a combination of 3 thermostable antibiotics (…

[HTML][HTML] A review on studies of marijuana for Alzheimer's disease–focusing on CBD, THC

SH Kim, JW Yang, KH Kim, JU Kim… - Journal of …, 2019 - ncbi.nlm.nih.gov
Objectives This study was to discuss the research trend of dementia treatment using cannabis
for the purpose of providing the basis of cannabis use for medical purposes in the future. …

Bifunctional effects of fucoidan on the expression of inducible nitric oxide synthase

JW Yang, SY Yoon, SJ Oh, SK Kim, KW Kang - … and Biophysical Research …, 2006 - Elsevier
Algal fucoidan is a marine sulfated polysaccharide with a wide variety of biological activities
including anti-thrombotic and anti-inflammatory effects. This study evaluated the effect of …

[HTML][HTML] Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells

HK Choi, JW Yang, SH Roh, CY Han… - Endocrine-related …, 2007 - erc.bioscientifica.com
Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem in breast cancer
patients. The transition from chemotherapy-responsive breast cancer cells to chemotherapy-…

Mechanics of femoral head osteonecrosis using three-dimensional finite element method

JW Yang, KH Koo, MC Lee, P Yang, MD Noh… - Archives of orthopaedic …, 2002 - Springer
A three-dimensional finite element model of a femoral head was developed using a surface
modeling technique. The distribution of the stress index S (S = effective stress / yield strength…

[HTML][HTML] Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease

L Barbier-Torres, B Murray, JW Yang, J Wang… - Nature …, 2022 - nature.com
MATα1 catalyzes the synthesis of S-adenosylmethionine, the principal biological methyl
donor. Lower MATα1 activity and mitochondrial dysfunction occur in alcohol-associated liver …

Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury

…, KM Kim, JH Yang, JH Kim, EH Jeong, JW Yang… - Toxicology and Applied …, 2019 - Elsevier
Ferroptosis is the non-apoptotic form of cell death caused by small molecules or conditions
that inhibit glutathione biosynthesis or resulting in iron-dependent accumulation of lipid …

[HTML][HTML] Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary …

HY Kay, JW Yang, TH Kim, B Kang, JH Ryu, R Jeon… - The Journal of …, 2010 - Elsevier
Cytoprotective effects of chemopreventive agents may be attributed to the induction of antioxidant
enzymes. Among these, the induction of glutamate-cysteine ligase (GCL) protects cells …