Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats

F Jin, Q Wu, YF Lu, QH Gong, JS Shi - European journal of pharmacology, 2008 - Elsevier
The present study was undertaken to investigate the neuroprotective effects of resveratrol
on 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease in rats. 6-OHDA-induced …

Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation

F Zhang, J Liu, JS Shi - European journal of pharmacology, 2010 - Elsevier
Neuroinflammation is an important contributor to pathogenesis of neurological disorders,
with microglial activation as a hallmark of neuroinflammation. Microglia serve the role of …

Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link

Y Zhang, N Huang, F Yan, H Jin, S Zhou, J Shi… - Behavioural brain …, 2018 - Elsevier
It is well known that Alzheimer’s disease (AD) is closely related to diabetes mellitus (DM),
and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and …

[PDF][PDF] Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline

JS Shi, JX Yu, XP Chen, RX Xu - Acta Pharmacologica Sinica, 2003 - Citeseer
The pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline
extracted from Uncaria rhynchophylla Miq Jacks were reviewed. The alkaloids mainly act on …

Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions

F Zhang, JS Shi, H Zhou, B Wilson, JS Hong… - Molecular …, 2010 - ASPET
Parkinson's disease (PD) is the second most common neurodegenerative disease characterized
by a progressive loss of dopamine (DA) neurons in the substantia nigra. Accumulating …

Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: role of reactive …

X Chen, K Xun, Q Wu, T Zhang, J Shi, G Du - Vascular pharmacology, 2007 - Elsevier
Studies have shown that oxidized low density lipoprotein (ox-LDL) elicits both necrotic and
apoptotic cell death and several mechanisms have been proposed. Ox-LDL induces reactive …

Fluoxetine protects neurons against microglial activation-mediated neurotoxicity

F Zhang, H Zhou, BC Wilson, JS Shi, JS Hong… - Parkinsonism & related …, 2012 - Elsevier
Neuroinflammation is closely associated with the pathogenesis of Parkinson's disease (PD)
and other neurological disorders. Increasing evidence suggests that inhibition of microglia-…

Icariin, a phoshphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling

…, H Jin, F Li, LS Li, YM Ma, JS Shi - International Journal …, 2014 - academic.oup.com
Phosphodiesterase-5 (PDE5) inhibitors are predominantly used in the treatment of erectile
dysfunction, and have been recently shown to have a potential therapeutic effect for the …

[HTML][HTML] Targeting MAPK pathways by naringenin modulates microglia M1/M2 polarization in lipopolysaccharide-stimulated cultures

B Zhang, YZ Wei, GQ Wang, DD Li, JS Shi… - Frontiers in cellular …, 2019 - frontiersin.org
Neuroinflammation is considered to be an important and inevitable pathological process
associated with all types of damages to, and disorders of, the central nervous system. The …

[HTML][HTML] Transcriptional factor NF-κB as a target for therapy in Parkinson's disease

PM Flood, L Qian, LJ Peterson, F Zhang, JS Shi… - Parkinson's …, 2011 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a neurodegenerative condition characterized by chronic
inflammation. Nuclear factor κB (NF-κB) is a family of inducible transcription factors that are …