User profiles for Johann Jauch
Johann JauchProfessor für Organische Chemie, Universität des Saarlandes Verified email at mx.uni-saarland.de Cited by 2309 |
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis
…, N Senninger, J Russell, J Jauch… - American Journal …, 2006 - journals.physiology.org
Recent clinical trials of the gum resin of Boswellia serrata have shown promising results in
patients with ulcerative colitis. The objective of this study was to determine whether a …
patients with ulcerative colitis. The objective of this study was to determine whether a …
Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids
…, J Madlung, L Franke, G Schneider, J Jauch… - Biochemical …, 2008 - Elsevier
Boswellic acids (BAs) are assumed as the anti-inflammatory principles of Boswellia species.
Initially, it was found that BAs inhibit leukotriene biosynthesis and 5-lipoxygenase (EC …
Initially, it was found that BAs inhibit leukotriene biosynthesis and 5-lipoxygenase (EC …
Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense
…, T Beckhaus, M Karas, J Jauch… - The Journal of …, 2009 - journals.aai.org
Frankincense preparations, used in folk medicine to cure inflammatory diseases, showed
anti-inflammatory effectiveness in animal models and clinical trials. Boswellic acids (BAs) …
anti-inflammatory effectiveness in animal models and clinical trials. Boswellic acids (BAs) …
Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2 Synthase-1
…, S Seitz, M Paul, SM Noha, J Jauch… - Journal of Natural …, 2014 - ACS Publications
The microsomal prostaglandin E 2 synthase (mPGES)-1 is the terminal enzyme in the
biosynthesis of prostaglandin (PG)E 2 from cyclooxygenase (COX)-derived PGH 2 . We previously …
biosynthesis of prostaglandin (PG)E 2 from cyclooxygenase (COX)-derived PGH 2 . We previously …
A thin‐layer chromatography method for the identification of three different olibanum resins (Boswellia serrata, Boswellia papyrifera and Boswellia carterii, respectively …
…, G Brüning, J Bergmann, J Jauch - Phytochemical …, 2012 - Wiley Online Library
Introduction Resins of the genus Boswellia are currently an interesting topic for
pharmaceutical research since several pharmacological activities (eg anti‐inflammatory, anti‐microbial, …
pharmaceutical research since several pharmacological activities (eg anti‐inflammatory, anti‐microbial, …
On the interference of boswellic acids with 5-lipoxygenase: Mechanistic studies in vitro and pharmacological relevance
Boswellic acids are pharmacologically active ingredients of frankincense with anti-inflammatory
properties. It was shown that in vitro 11-keto-boswellic acids inhibit 5-lipoxygenase (5-LO…
properties. It was shown that in vitro 11-keto-boswellic acids inhibit 5-lipoxygenase (5-LO…
[PDF][PDF] Mitochondrial chaperonin HSP60 is the apoptosis-related target for myrtucommulone
The acylphloroglucinol myrtucommulone A (MC) causes mitochondrial dysfunctions by direct
interference leading to apoptosis in cancer cells, but the molecular targets involved are …
interference leading to apoptosis in cancer cells, but the molecular targets involved are …
A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome …
…, F Hannemann, J Zapp, D Hartmann, J Jauch… - Applied microbiology …, 2012 - Springer
The use of cytochromes P450 for the regio- and stereoselective hydroxylation of non-activated
carbon atoms in biotechnological applications reflects an efficient and cost-effective …
carbon atoms in biotechnological applications reflects an efficient and cost-effective …
Total synthesis of myrtucommulone A
In a one‐step conversion, commercially available or known compounds are connected to
form myrtucommulone A, an anti‐inflammatory and apoptosis‐inducing substance from the …
form myrtucommulone A, an anti‐inflammatory and apoptosis‐inducing substance from the …
Eine kurze Totalsynthese von Kuehneromycin A
J Jauch - Angewandte Chemie, 2000 - Wiley Online Library
In nur elf Schritten kann der Reverse‐Transkriptase‐Inhibitor Kuehneromycin A 1
synthetisiert werden (siehe Bild). Zum Einsatz kommen dabei eine neue Variante der Baylis‐Hillman‐…
synthetisiert werden (siehe Bild). Zum Einsatz kommen dabei eine neue Variante der Baylis‐Hillman‐…