User profiles for Johann Jauch

Johann Jauch

Professor für Organische Chemie, Universität des Saarlandes
Verified email at mx.uni-saarland.de
Cited by 2309

Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis

…, N Senninger, J Russell, J Jauch… - American Journal …, 2006 - journals.physiology.org
Recent clinical trials of the gum resin of Boswellia serrata have shown promising results in
patients with ulcerative colitis. The objective of this study was to determine whether a …

Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids

…, J Madlung, L Franke, G Schneider, J Jauch… - Biochemical …, 2008 - Elsevier
Boswellic acids (BAs) are assumed as the anti-inflammatory principles of Boswellia species.
Initially, it was found that BAs inhibit leukotriene biosynthesis and 5-lipoxygenase (EC …

Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense

…, T Beckhaus, M Karas, J Jauch… - The Journal of …, 2009 - journals.aai.org
Frankincense preparations, used in folk medicine to cure inflammatory diseases, showed
anti-inflammatory effectiveness in animal models and clinical trials. Boswellic acids (BAs) …

Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2 Synthase-1

…, S Seitz, M Paul, SM Noha, J Jauch… - Journal of Natural …, 2014 - ACS Publications
The microsomal prostaglandin E 2 synthase (mPGES)-1 is the terminal enzyme in the
biosynthesis of prostaglandin (PG)E 2 from cyclooxygenase (COX)-derived PGH 2 . We previously …

A thin‐layer chromatography method for the identification of three different olibanum resins (Boswellia serrata, Boswellia papyrifera and Boswellia carterii, respectively …

…, G Brüning, J Bergmann, J Jauch - Phytochemical …, 2012 - Wiley Online Library
Introduction Resins of the genus Boswellia are currently an interesting topic for
pharmaceutical research since several pharmacological activities (eg anti‐inflammatory, anti‐microbial, …

On the interference of boswellic acids with 5-lipoxygenase: Mechanistic studies in vitro and pharmacological relevance

…, B Jazzar, H Northoff, C Skarke, J Jauch… - European journal of …, 2009 - Elsevier
Boswellic acids are pharmacologically active ingredients of frankincense with anti-inflammatory
properties. It was shown that in vitro 11-keto-boswellic acids inhibit 5-lipoxygenase (5-LO…

[PDF][PDF] Mitochondrial chaperonin HSP60 is the apoptosis-related target for myrtucommulone

…, H Müller, S König, N Wielsch, A Svatoš, J Jauch… - Cell chemical …, 2017 - cell.com
The acylphloroglucinol myrtucommulone A (MC) causes mitochondrial dysfunctions by direct
interference leading to apoptosis in cancer cells, but the molecular targets involved are …

A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome …

…, F Hannemann, J Zapp, D Hartmann, J Jauch… - Applied microbiology …, 2012 - Springer
The use of cytochromes P450 for the regio- and stereoselective hydroxylation of non-activated
carbon atoms in biotechnological applications reflects an efficient and cost-effective …

Total synthesis of myrtucommulone A

…, D Blaesius, A Koeberle, O Werz, J Jauch - Angewandte Chemie …, 2010 - infona.pl
In a one‐step conversion, commercially available or known compounds are connected to
form myrtucommulone A, an anti‐inflammatory and apoptosis‐inducing substance from the …

Eine kurze Totalsynthese von Kuehneromycin A

J Jauch - Angewandte Chemie, 2000 - Wiley Online Library
In nur elf Schritten kann der Reverse‐Transkriptase‐Inhibitor Kuehneromycin A 1
synthetisiert werden (siehe Bild). Zum Einsatz kommen dabei eine neue Variante der Baylis‐Hillman‐…