Nicotine activation of α4* receptors: sufficient for reward, tolerance, and sensitization
AR Tapper, SL McKinney, R Nashmi, J Schwarz… - Science, 2004 - science.org
The identity of nicotinic receptor subtypes sufficient to elicit both the acute and chronic effects
of nicotine dependence is unknown. We engineered mutant mice with α4 nicotinic subunits …
of nicotine dependence is unknown. We engineered mutant mice with α4 nicotinic subunits …
[HTML][HTML] A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
…, T Arendt, MH De Angelis, J Fischer, J Schwarz… - Cell, 2009 - cell.com
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have
been positively selected during human evolution due to effects on aspects of speech and …
been positively selected during human evolution due to effects on aspects of speech and …
Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells
…, M Maisel, H Lerche, J Schwarz… - Journal of cell …, 2004 - journals.biologists.com
Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to
differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. …
differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. …
Psychosis pathways converge via D2High dopamine receptors
P Seeman, J Schwarz, JF Chen, H Szechtman… - Synapse, 2006 - Wiley Online Library
The objective of this review is to identify a target or biomarker of altered neurochemical
sensitivity that is common to the many animal models of human psychoses associated with street …
sensitivity that is common to the many animal models of human psychoses associated with street …
Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in …
…, JF Gildehaus, CT Wetter, C Trenkwalder, J Schwarz… - Sleep, 2003 - academic.oup.com
Study Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized
by complex behavior during REM sleep. The etiology of this disorder is still unknown, but …
by complex behavior during REM sleep. The etiology of this disorder is still unknown, but …
Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
…, BO Boehm, PM Carvey, A Kupsch, J Schwarz - Experimental …, 2001 - Elsevier
We report on generation of dopamine neurons from long-term cultures of human fetal
mesencephalic precursor cells. These CNS precursor cells were successfully expanded in vitro …
mesencephalic precursor cells. These CNS precursor cells were successfully expanded in vitro …
Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study
A Gerhard, J Schwarz, R Myers, R Wise, RB Banati - Neuroimage, 2005 - Elsevier
We obtained [ 11 C](R)-PK11195 PET scans in six patients at different time points between
3 and 150 days after onset of ischemic stroke in order to measure the time course of …
3 and 150 days after onset of ischemic stroke in order to measure the time course of …
Transcriptional Profiles of CD133+ and CD133− Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin
Glioblastoma multiforme (GBM) is paradigmatic for the investigation of cancer stem cells (CSC)
in solid tumors. Growing evidence suggests that different types of CSC lead to the …
in solid tumors. Growing evidence suggests that different types of CSC lead to the …
[PDF][PDF] RGS9 modulates dopamine signaling in the basal ganglia
Z Rahman, J Schwarz, SJ Gold, V Zachariou, MN Wein… - Neuron, 2003 - cell.com
Regulators of G protein signaling (RGS) modulate heterotrimeric G proteins in part by serving
as GTPase-activating proteins for Gα subunits. We examined a role for RGS9-2, an RGS …
as GTPase-activating proteins for Gα subunits. We examined a role for RGS9-2, an RGS …
Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open …
…, M Schulz, T Schütz, J Schwarz… - The Lancet …, 2021 - thelancet.com
Background SARS-CoV-2 entry in human cells depends on angiotensin-converting enzyme
2, which can be upregulated by inhibitors of the renin–angiotensin system (RAS). We aimed …
2, which can be upregulated by inhibitors of the renin–angiotensin system (RAS). We aimed …