User profiles for John D. Lambris

John D. Lambris

University of Pennsylvania
Verified email at lambris.com
Cited by 69558

[HTML][HTML] The classical complement cascade mediates CNS synapse elimination

…, A Sher, AM Litke, JD Lambris, SJ Smith, SWM John… - Cell, 2007 - cell.com
During development, the formation of mature neural circuits requires the selective elimination
of inappropriate synaptic connections. Here we show that C1q, the initiating protein in the …

Complement: a key system for immune surveillance and homeostasis

D Ricklin, G Hajishengallis, K Yang, JD Lambris - Nature immunology, 2010 - nature.com
Nearly a century after the significance of the human complement system was recognized,
we have come to realize that its functions extend far beyond the elimination of microbes. …

Generation of C5a in the absence of C3: a new complement activation pathway

…, D Rittirsch, TA Neff, SR McGuire, JD Lambris… - Nature medicine, 2006 - nature.com
Complement-mediated tissue injury in humans occurs upon deposition of immune complexes,
such as in autoimmune diseases and acute respiratory distress syndrome. Acute lung …

[HTML][HTML] Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

…, I Mitroulis, G Germanidis, JD Lambris… - The Journal of …, 2020 - Am Soc Clin Investig
Emerging data indicate that complement and neutrophils contribute to the maladaptive
immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby …

[PDF][PDF] Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement

…, ML McIntosh, A Alsam, KL Kirkwood, JD Lambris… - Cell host & …, 2011 - cell.com
Porphyromonas gingivalis is a low-abundance oral anaerobic bacterium implicated in
periodontitis, a polymicrobial inflammatory disease, and the associated systemic conditions. …

Complement evasion by human pathogens

JD Lambris, D Ricklin, BV Geisbrecht - Nature Reviews Microbiology, 2008 - nature.com
The human immune system has developed an elaborate network of cascades for dealing with
microbial intruders. Owing to its ability to rapidly recognize and eliminate microorganisms, …

[HTML][HTML] Complement as a target in COVID-19?

…, C Garlanda, F Ciceri, JD Lambris - Nature Reviews …, 2020 - nature.com
There is an urgent need to develop effective therapies for COVID-19. Here, we urge
immunologists and clinicians to consider the potential of targeting the complement system in …

Modulation of the antitumor immune response by complement

…, A Koutoulaki, C Gerard, G Coukos, JD Lambris - Nature …, 2008 - nature.com
The involvement of complement-activation products in promoting tumor growth has not yet
been recognized. Here we show that the generation of complement C5a in a tumor …

[HTML][HTML] Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

…, MC Caroll, RA Wetsel, JD Lambris… - The Journal of …, 2003 - Am Soc Clin Investig
Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in
the presence of antiphospholipid (aPL) Ab’s. Currently, therapy for pregnant women with …

Drusen complement components C3a and C5a promote choroidal neovascularization

…, JV Sarma, SR Barnum, JD Lambris… - Proceedings of the …, 2006 - National Acad Sciences
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark …