User profiles for John D. Lambris
John D. LambrisUniversity of Pennsylvania Verified email at lambris.com Cited by 69558 |
[HTML][HTML] The classical complement cascade mediates CNS synapse elimination
During development, the formation of mature neural circuits requires the selective elimination
of inappropriate synaptic connections. Here we show that C1q, the initiating protein in the …
of inappropriate synaptic connections. Here we show that C1q, the initiating protein in the …
Complement: a key system for immune surveillance and homeostasis
Nearly a century after the significance of the human complement system was recognized,
we have come to realize that its functions extend far beyond the elimination of microbes. …
we have come to realize that its functions extend far beyond the elimination of microbes. …
Generation of C5a in the absence of C3: a new complement activation pathway
Complement-mediated tissue injury in humans occurs upon deposition of immune complexes,
such as in autoimmune diseases and acute respiratory distress syndrome. Acute lung …
such as in autoimmune diseases and acute respiratory distress syndrome. Acute lung …
[HTML][HTML] Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis
Emerging data indicate that complement and neutrophils contribute to the maladaptive
immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby …
immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby …
[PDF][PDF] Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement
…, ML McIntosh, A Alsam, KL Kirkwood, JD Lambris… - Cell host & …, 2011 - cell.com
Porphyromonas gingivalis is a low-abundance oral anaerobic bacterium implicated in
periodontitis, a polymicrobial inflammatory disease, and the associated systemic conditions. …
periodontitis, a polymicrobial inflammatory disease, and the associated systemic conditions. …
Complement evasion by human pathogens
The human immune system has developed an elaborate network of cascades for dealing with
microbial intruders. Owing to its ability to rapidly recognize and eliminate microorganisms, …
microbial intruders. Owing to its ability to rapidly recognize and eliminate microorganisms, …
[HTML][HTML] Complement as a target in COVID-19?
…, C Garlanda, F Ciceri, JD Lambris - Nature Reviews …, 2020 - nature.com
There is an urgent need to develop effective therapies for COVID-19. Here, we urge
immunologists and clinicians to consider the potential of targeting the complement system in …
immunologists and clinicians to consider the potential of targeting the complement system in …
Modulation of the antitumor immune response by complement
…, A Koutoulaki, C Gerard, G Coukos, JD Lambris - Nature …, 2008 - nature.com
The involvement of complement-activation products in promoting tumor growth has not yet
been recognized. Here we show that the generation of complement C5a in a tumor …
been recognized. Here we show that the generation of complement C5a in a tumor …
[HTML][HTML] Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
…, MC Caroll, RA Wetsel, JD Lambris… - The Journal of …, 2003 - Am Soc Clin Investig
Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in
the presence of antiphospholipid (aPL) Ab’s. Currently, therapy for pregnant women with …
the presence of antiphospholipid (aPL) Ab’s. Currently, therapy for pregnant women with …
Drusen complement components C3a and C5a promote choroidal neovascularization
…, JV Sarma, SR Barnum, JD Lambris… - Proceedings of the …, 2006 - National Acad Sciences
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark …
industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark …