Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified
by the 'side-population' (SP) phenotype. Although it has been assumed that expression of …

MDR1 (P‐glycoprotein) is an important factor in the disposition of many drugs, and the
involved processes often exhibit considerable interindividual variability that may be genetically …

Our studies demonstrate that the ABC transporter and marker of stem and progenitor cells
known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival …

Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral
DNA polymerases, are a common component of highly active anti-retroviral therapy (HAART)…

Hematopoietic stem cells (HSCs) can be identified by a “side population” (SP) phenotype.
Previous studies have implicated the ATP binding cassette transporter genes Mdr1a/1b and/or …

Enzymes within the P450IIIA (CYP3A) subfamily appear to account for significant "first pass"
metabolism of some drugs in the intestine. To identify which of the known P450IIIA genes …

Xenobiotics frequently induce proteins involved in their detoxification. Because many drugs
that are metabolized by human cytochromes P450 (CYP) 3A4 and 3A5 are also transported …

The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To
explore this role, we generated Mrp4-deficient mice. Unexpectedly, these mice showed …

MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of multiple
cell lineages, is also among the most highly amplified genes in cancer. Although MCL-1 is …

The movement of anionic porphyrins (for example, haem) across intracellular membranes is
crucial to many biological processes, but their mitochondrial translocation and coordination …