Pathologic thrombosis is a major cause of mortality. Hemolytic-uremic syndrome (HUS)
features episodes of small-vessel thrombosis resulting in microangiopathic hemolytic anemia, …

The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …

Platelets are abundant, small, anucleate circulating cells, serving many emerging
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis, injury …

Platelets have been shown to be associated with pathophysiological processes beyond
thrombosis, demonstrating critical additional roles in homeostatic processes, such as immune …

The a, ARs are important mediators of sympathetic nervous system responses, particularly
those involved in cardiovascular homeostasis, such as arteriolar smooth muscle constriction …

Diabetes mellitus (DM) is a complex metabolic disorder arising from lack of insulin production
or insulin resistance (Diagnosis and classification of diabetes mellitus, 2007 ). DM is a …

Background An important feature of severe acute respiratory syndrome coronavirus 2
pathogenesis is COVID-19-associated coagulopathy, characterised by increased thrombotic and …

Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19,
but the mechanisms involved remain poorly understood. We carried out proteomic …

Background— Smooth muscle cells (SMCs) are remarkably plastic. Their reversible differentiation
is required for growth and wound healing but also contributes to pathologies such as …

The hedgehog (Hh) signalling pathway has an evolutionarily conserved role in patterning
fields of cells during metazoan development, and is inappropriately activated in cancer 1 , 2 . …