Mitogen stimulation of cytoskeletal changes and c-jun amino-terminal kinases is mediated
by Rac small guanine nucleotide-binding proteins. Vav, a guanosine diphosphate (GDP)–…

The demonstration of in vivo arachidonic acid epoxidation and ω-hydroxylation established
the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways …

The positively charged lysine residue plays an important role in protein folding and functions.
Neutralization of the charge often has a profound impact on the substrate proteins. …

A cDNA encoding a human cytochrome P450 arachidonic acid epoxygenase was isolated
from a human liver cDNA library. Sequence analysis revealed that this 1,876-base pair cDNA …

Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to
respond to host adrenergic signaling molecules and bacterial signals in order to promote the …

The influence of inositol phosphates and phosphoinositides on the α isoform of the RAC-protein
kinase B (RAC/PKB) was studied using purified wild type and mutant kinase …

The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from expression
of a gene super-family that currently contains around 1000 members in species ranging …

In the brain, pressure-induced myogenic constriction of cerebral arteriolar muscle contributes
to autoregulation of cerebral blood flow (CBF). This study examined the role of 20-HETE in …

The present study examined the effects of 20-hydroxyeicosatetraenoic acid (20-HETE) and
17-octadecynoic acid (17-ODYA), an inhibitor of the metabolism of arachidonic acid by P-450…

Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP)
epoxygenases have beneficial effects in certain cardiovascular and kidney diseases. …