User profiles for Jonathan Z. Long
Jonathan Z. LongAssistant Professor, Stanford University Verified email at stanford.edu Cited by 17130 |
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
Phospholipase A 2 (PLA 2 ) enzymes are considered the primary source of arachidonic acid
for cyclooxygenase (COX)–mediated biosynthesis of prostaglandins. Here, we show that a …
for cyclooxygenase (COX)–mediated biosynthesis of prostaglandins. Here, we show that a …
The metabolic serine hydrolases and their functions in mammalian physiology and disease
JZ Long, BF Cravatt - Chemical reviews, 2011 - ACS Publications
Serine hydrolases (SHs) consist of> 200 enzymes in humans characterized by the presence
of an active site serine that is used for the hydrolysis of substrates. The membership of this …
of an active site serine that is used for the hydrolysis of substrates. The membership of this …
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
…, JC Lo, KA Rasbach, EA Boström, JH Choi, JZ Long… - Nature, 2012 - nature.com
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized
effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-…
effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-…
[HTML][HTML] Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
Tumor cells display progressive changes in metabolism that correlate with malignancy, including
development of a lipogenic phenotype. How stored fats are liberated and remodeled to …
development of a lipogenic phenotype. How stored fats are liberated and remodeled to …
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the
cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic …
cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic …
[HTML][HTML] Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
RR Rao, JZ Long, JP White, KJ Svensson, J Lou… - Cell, 2014 - cell.com
Exercise training benefits many organ systems and offers protection against metabolic
disorders such as obesity and diabetes. Using the recently identified isoform of PGC1-α (PGC1-α4…
disorders such as obesity and diabetes. Using the recently identified isoform of PGC1-α (PGC1-α4…
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
JE Schlosburg, JL Blankman, JZ Long… - Nature …, 2010 - nature.com
Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to
pharmacological tolerance and receptor desensitization in the nervous system. We found that a …
pharmacological tolerance and receptor desensitization in the nervous system. We found that a …
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
…, S Fung, M Lafourcade, JP Alexander, JZ Long… - Nature …, 2010 - nature.com
The endocannabinoid 2-arachidonoylglycerol (2-AG) regulates neurotransmission and
neuroinflammation by activating CB 1 cannabinoid receptors on neurons and CB 2 cannabinoid …
neuroinflammation by activating CB 1 cannabinoid receptors on neurons and CB 2 cannabinoid …
[PDF][PDF] A smooth muscle-like origin for beige adipocytes
Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform
chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal …
chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal …
[PDF][PDF] Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain
K Ahn, DS Johnson, M Mileni, D Beidler, JZ Long… - Chemistry & biology, 2009 - cell.com
Endocannabinoids are lipid signaling molecules that regulate a wide range of mammalian
behaviors, including pain, inflammation, and cognitive/emotional state. The endocannabinoid …
behaviors, including pain, inflammation, and cognitive/emotional state. The endocannabinoid …