The growth of siRNA-based therapeutics: Updated clinical studies

…, R Bahal, TP Rasmussen, JE Manautou… - Biochemical …, 2021 - Elsevier
More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …

Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity

CI Ghanem, MJ Pérez, JE Manautou… - Pharmacological …, 2016 - Elsevier
Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to
be safe when administered within its therapeutic range, but in cases of acute intoxication, …

Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease

LM Aleksunes, JE Manautou - Toxicologic pathology, 2007 - journals.sagepub.com
Transcription factor NF-E2-related factor 2 (Nrf2) belongs to the basic region-leucine zipper
family and is activated in response to electrophiles and reactive oxygen species. Nrf2 …

Molecular mechanisms underlying chemical liver injury

X Gu, JE Manautou - Expert reviews in molecular medicine, 2012 - cambridge.org
The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

…, NJ Cherrington, CD Klaassen, JE Manautou - Toxicology and applied …, 2008 - Elsevier
The transcription factor NFE2-related factor 2 (Nrf2) mediates detoxification and antioxidant
gene transcription following electrophile exposure and oxidative stress. Mice deficient in Nrf2 …

Absorption, distribution, metabolism, and excretion of US Food and Drug Administration–Approved antisense oligonucleotide drugs

…, S Nair, R Bahal, TP Rasmussen, JE Manautou… - Drug Metabolism and …, 2022 - ASPET
Absorption, distribution, metabolism, and excretion (ADME) are the key biologic processes
for determination of a drug’s pharmacokinetic parameters, which have direct impacts on …

[HTML][HTML] Rethinking subthreshold effects in regulatory chemical risk assessments

…, JE Manautou, MN Moore, E Paoletti… - … science & technology, 2022 - ACS Publications
A great number of dose− response studies indicate that hormesis is a common phenomenon,
occurring in numerous organisms exposed to singular or combined environmental …

Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity

Q Cheng, LM Aleksunes, JE Manautou… - Molecular …, 2008 - ACS Publications
Obesity and type II diabetes pose a serious human health risk. Obese or diabetic patients
usually take prescription drugs that require hepatic and renal metabolism and transport, and …

Adverse drug reactions and toxicity of the food and drug administration–approved antisense oligonucleotide drugs

…, R Bahal, X Zhong, JE Manautou - Drug Metabolism and …, 2022 - ASPET
The market for large molecule biologic drugs has grown rapidly, including antisense
oligonucleotide (ASO) drugs. ASO drugs work as single-stranded synthetic oligonucleotides that …

Green tea extract provides extensive Nrf2‐independent protection against lipid accumulation and NFκB pro‐inflammatory responses during nonalcoholic …

…, PR Rohrer, JE Manautou… - Molecular nutrition & …, 2016 - Wiley Online Library
Scope Green tea extract (GTE) reduces liver steatosis and inflammation during nonalcoholic
steatohepatitis (NASH). We hypothesized GTE would mitigate NASH in a nuclear factor …