Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation
…, P Fürst, H Hanenberg, J Abel… - Proceedings of the …, 2007 - National Acad Sciences
UVB radiation-induced signaling in mammalian cells involves two major pathways: one that
is initiated through the generation of DNA photoproducts in the nucleus and a second one …
is initiated through the generation of DNA photoproducts in the nucleus and a second one …
An introduction to the molecular basics of aryl hydrocarbon receptor biology
J Abel, T Haarmann-Stemmann - 2010 - degruyter.com
Depending on their chemical structure and properties, environmental chemicals and other
xenobiotics that enter the cell can affect cellular function by either nonselective binding to …
xenobiotics that enter the cell can affect cellular function by either nonselective binding to …
Polybrominated Diphenyl Ethers Induce Developmental Neurotoxicity in a Human in Vitro Model: Evidence for Endocrine Disruption
…, NH Nguyen, TS Scanlan, J Abel… - Environmental …, 2010 - ehp.niehs.nih.gov
Background Polybrominated diphenyl ethers (PBDEs) are persistent and bioaccumulative
flame retardants, which are found in rising concentrations in human tissues. They are of …
flame retardants, which are found in rising concentrations in human tissues. They are of …
Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing
M Moors, TD Rockel, J Abel, JE Cline… - Environmental …, 2009 - ehp.niehs.nih.gov
Background Developmental neurotoxicity (DNT) of environmental chemicals is a serious threat
to human health. Current DNT testing guidelines propose investigations in rodents, which …
to human health. Current DNT testing guidelines propose investigations in rodents, which …
Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways
T Haarmann-Stemmann, H Bothe, J Abel - Biochemical pharmacology, 2009 - Elsevier
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant,
which causes a variety of severe health effects, eg immunosuppression, hepatotoxicity, and …
which causes a variety of severe health effects, eg immunosuppression, hepatotoxicity, and …
Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein
J Abel, N de Ruiter - Toxicology letters, 1989 - Elsevier
The effect of metallothionein (MT) on hydroxyl-radical-induced DNA damage was
investigated in an in-vitro study. The degradation of DNA as demonstrated by agarose gel …
investigated in an in-vitro study. The degradation of DNA as demonstrated by agarose gel …
Xenobiotic metabolism capacities of human skin in comparison with a 3D‐epidermis model and keratinocyte‐based cell culture as in vitro alternatives for chemical …
…, J Krutmann, RJ Edwards, J Abel… - Experimental …, 2012 - Wiley Online Library
The 7th Amendment to the EU Cosmetics Directive prohibits the use of animals in cosmetic
testing for certain endpoints, such as genotoxicity. Therefore, skin in vitro models have to …
testing for certain endpoints, such as genotoxicity. Therefore, skin in vitro models have to …
Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility
…, DR Marchington, S Donat, HC Schuppe, J Abel… - Nature …, 2001 - nature.com
Human mitochondrial DNA polymerase, encoded by POLG, contains a polyglutamine tract
encoded by a CAG microsatellite repeat 1, 2. Analysis of POLG genotypes in different …
encoded by a CAG microsatellite repeat 1, 2. Analysis of POLG genotypes in different …
Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis
…, R Brigelius-Flohe, K Schottker, J Abel… - Nutrition and …, 2004 - Taylor & Francis
The trace element selenium is discussed as a chemopreventive agent in colorectal
carcinogenesis. Selenocysteine-containing proteins, so-called selenoproteins, represent potential …
carcinogenesis. Selenocysteine-containing proteins, so-called selenoproteins, represent potential …
Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors
…, NH Nguyen, TS Scanlan, J Abel - Environmental health …, 2005 - ehp.niehs.nih.gov
Polychlorinated biphenyls (PCBs) are ubiquitous environmental chemicals that accumulate
in adipose tissues over the food chain. Epidemiologic studies have indicated that PCBs …
in adipose tissues over the food chain. Epidemiologic studies have indicated that PCBs …