Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus

KA Berg, S Maayani, J Goldfarb, C Scaramellini… - Molecular …, 1998 - ASPET
There are many examples of a single receptor coupling directly to more than one cellular
signal transduction pathway. Although traditional receptor theory allows for activation of …

The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy

…, JH Li, L Zhang, S Wallenstein, J Goldfarb… - Journal of Allergy and …, 2005 - Elsevier
BACKGROUND: Peanut allergy is potentially life threatening. There is no curative therapy
for this disorder. We previously found that an herbal formula, food allergy herbal formula (FAHF…

Systems biology primer: the basic methods and approaches

I Tavassoly, J Goldfarb, R Iyengar - Essays in biochemistry, 2018 - portlandpress.com
Systems biology is an integrative discipline connecting the molecular components within a
single biological scale and also among different scales (eg cells, tissues and organ systems) …

Systems pharmacology of adverse event mitigation by drug combinations

…, L Benard, JJ Badimon, RJ Hajjar, J Goldfarb… - Science translational …, 2013 - science.org
Drugs are designed for therapy, but medication-related adverse events are common, and
risk/benefit analysis is critical for determining clinical use. Rosiglitazone, an efficacious …

Licorice Flavonoids Inhibit Eotaxin-1 Secretion by Human Fetal Lung Fibroblasts in Vitro

…, R Wang, D Holmes, J Goldfarb… - Journal of agricultural …, 2009 - ACS Publications
Glycyrrhiza uralensis (Gan-Cao), commonly called “licorice”, is one of the most commonly
used herbs in traditional Chinese medicine (TCM). In the United States, licorice products are …

Glycyrrhiza uralensis Flavonoids Present in Anti‐Asthma Formula, ASHMITM, Inhibit Memory Th2 Responses in Vitro and in Vivo

…, J Bolleddula, S Doddaga, J Goldfarb… - Phytotherapy …, 2013 - Wiley Online Library
Allergic asthma is associated with Th2‐mediated inflammation. Several flavonoids were
isolated from Glycyrrhiza uralensis, one of the herbs in the anti‐asthma herbal medicine …

Network analysis of FDA approved drugs and their targets

A Ma'ayan, SL Jenkins, J Goldfarb… - Mount Sinai Journal of …, 2007 - Wiley Online Library
The global relationship between drugs that are approved for therapeutic use and the human
genome is not known. We employed graph‐theory methods to analyze the Federal Food …

Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-γ–producing CD8+ T cells

KD Srivastava, C Qu, T Zhang, J Goldfarb… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Food allergy is a serious and sometimes fatal condition for which there is no
cure. We previously reported that Food Allergy Herbal Formula (FAHF)–2) protected peanut…

Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells …

…, D Weir, J Tversky, RL Miller, J Goldfarb… - International …, 2015 - Elsevier
Asthma is a heterogeneous airway inflammatory disease, which is associated with Th2
cytokine-driven inflammation and non-Th2, TNF-α mediated inflammation. Unlike Th2 mediated …

[HTML][HTML] Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

…, B Hu, M Mahajan, JM Gallo, J Goldfarb… - Nature …, 2020 - nature.com
Kinase inhibitors (KIs) represent an important class of anti-cancer drugs. Although
cardiotoxicity is a serious adverse event associated with several KIs, the reasons remain poorly …