User profiles for Joseph T. Ortega
 | Joseph T. OrtegaCase Western Reserve University Verified email at case.edu Cited by 993 |
[HTML][HTML] Class AG protein-coupled receptor antagonist famotidine as a therapeutic alternative against SARS-CoV2: an in silico analysis
The pandemic associated with Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV2)
and its disease named COVID-19 challenged the scientific community to discover …
and its disease named COVID-19 challenged the scientific community to discover …
[HTML][HTML] The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro
JT Ortega, AI Suárez, ML Serrano, J Baptista… - AIDS research and …, 2017 - Springer
Background Plant extracts are sources of valuable compounds with biological activity,
especially for the anti-proliferative activity against pathogens or tumor cells. Myricetin is a …
especially for the anti-proliferative activity against pathogens or tumor cells. Myricetin is a …
Protective effects of flavonoids in acute models of light-induced retinal degeneration
Degeneration of photoreceptors caused by excessive illumination, inherited mutations, or
aging is the principal pathology of blinding diseases. Pharmacological compounds that …
aging is the principal pathology of blinding diseases. Pharmacological compounds that …
[HTML][HTML] Flavonoids enhance rod opsin stability, folding, and self-association by directly binding to ligand-free opsin and modulating its conformation
Rhodopsin (Rho) is a visual G protein–coupled receptor expressed in the rod photoreceptors
of the eye, where it mediates transmission of a light signal into a cell and converts this …
of the eye, where it mediates transmission of a light signal into a cell and converts this …
Understanding severe acute respiratory syndrome coronavirus 2 replication to design efficient drug combination therapies
Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and its disease CO-VID-19 has strongly encouraged the search for antiviral compounds…
and its disease CO-VID-19 has strongly encouraged the search for antiviral compounds…
[HTML][HTML] Galanin receptor 3− A new pharmacological target in retina degeneration
The neuropeptide galanin receptor 3 (GALR3) is a class AG protein-coupled receptor (GPCR)
broadly expressed in the nervous system, including the retina. GALR3 is involved in the …
broadly expressed in the nervous system, including the retina. GALR3 is involved in the …
[HTML][HTML] Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal
FJ Roushar, AG McKee, CP Kuntz, JT Ortega… - Journal of Biological …, 2022 - ASBMB
Over 100 mutations in the rhodopsin gene have been linked to a spectrum of retinopathies
that include retinitis pigmentosa and congenital stationary night blindness. Though most of …
that include retinitis pigmentosa and congenital stationary night blindness. Though most of …
Remarkable in vitro anti-HIV activity of new silver (I)–and gold (I)–N-heterocyclic carbene complexes. Synthesis, DNA binding and biological evaluation
A novel metallomacrocyclic silver complex [Ag(C 13 H 13 N 5 )] 2 Br 2 1 and a bimetallic
bridged gold complex [Au 2 (C 13 H 13 N 5 )Cl 2 ] 2 derived from 2,6-bis(3-methylimidazolin-2-…
bridged gold complex [Au 2 (C 13 H 13 N 5 )Cl 2 ] 2 derived from 2,6-bis(3-methylimidazolin-2-…
Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants
JT Ortega, AG McKee, FJ Roushar… - Human Molecular …, 2022 - academic.oup.com
The correct expression of folded, functional rhodopsin (Rho) is critical for visual perception.
However, this seven-transmembrane helical G protein-coupled receptor is prone to …
However, this seven-transmembrane helical G protein-coupled receptor is prone to …
[HTML][HTML] The retinoid and non-retinoid ligands of the rod visual G protein-coupled receptor
JT Ortega, B Jastrzebska - International Journal of Molecular Sciences, 2019 - mdpi.com
G protein-coupled receptors (GPCRs) play a predominant role in the drug discovery effort.
These cell surface receptors are activated by a variety of specific ligands that bind to the …
These cell surface receptors are activated by a variety of specific ligands that bind to the …