Fat intake affects adiposity, comorbidity factors, and energy metabolism of Sprague‐Dawley rats

…, J Cook, C Farley, M Van Heek, JJ Hwa - Obesity …, 2002 - Wiley Online Library
Objective: Childhood obesity is an emerging health problem. This study assesses the effects
of three levels of dietary fat (10%, 32%, and 45% measured by kilocalories) on weight gain, …

Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice

JJ Hwa, AB Fawzi, MP Graziano… - American Journal …, 1997 - journals.physiology.org
Obesity occurs whenever energy intake exceeds energy expenditure. The ob gene product
leptin is a potent anorectic agent when administered to ob/ob mice, but its effects on energy …

Comparison of acetylcholine-dependent relaxation in large and small arteries of rat mesenteric vascular bed

JJ Hwa, L Ghibaudi, P Williams… - American Journal of …, 1994 - journals.physiology.org
The relative contributions of nitric oxide (NO) to in vitro relaxation responses elicited by
acetylcholine (ACh) were compared in vessels of different sizes from the rat mesenteric vascular …

Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice

…, G Tetzloff, H Davis Jr, M van Heek, JJ Hwa - European journal of …, 2008 - Elsevier
Ezetimibe is a novel cholesterol and plant sterol absorption inhibitor that reduces plasma
low-density lipoprotein–cholesterol by selectively binding to the intestinal cholesterol …

Activation of the NPY Y5 receptor regulates both feeding and energy expenditure

JJ Hwa, MB Witten, P Williams… - American Journal …, 1999 - journals.physiology.org
Intracerebroventricular (ICV) administration of neuropeptide Y (NPY) has been shown to
decrease energy expenditure, induce hypothermia, and stimulate food intake. Recent evidence …

Identification of potent and selective neuropeptide Y Y1 receptor agonists with orexigenic activity in vivo

D Mullins, D Kirby, J Hwa, M Guzzi, J Rivier… - Molecular …, 2001 - ASPET
Neuropeptide Y (NPY) binds to a family of G-protein coupled receptors termed Y 1 , Y 2 , Y 3
, Y 4 , Y 5 , and y 6 . The use of various receptor subtype-selective agonists and antagonists …

Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats

JJ Hwa, L Ghibaudi, J Gao… - American Journal of …, 2001 - journals.physiology.org
Melanocortins play a critical role in appetite and body weight regulation, because manipulations
of this pathway can lead to the development of obesity in several animal models. The …

Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial

…, S Maddin, YP Poulin, DC Wilson, J Hwa… - Journal of the American …, 2006 - Elsevier
BACKGROUND: A new 0.3% gel formulation of adapalene has been developed. OBJECTIVE:
We sought to provide evidence of the superiority of adapalene gel 0.3% over adapalene …

Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells

JJ Hwa, L Ghibaudi, P Williams, M Chintala… - Circulation …, 1996 - Am Heart Assoc
The thrombin receptor was the first cloned G protein–coupled receptor reported to be
activated by proteolytic cleavage of its extracellular amino terminus. A second proteinase-activated …

Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet

J Gao, L Ghibaudi, M Van Heek, JJ Hwa - Brain research, 2002 - Elsevier
A subset of Sprague–Dawley rats developed persistent obesity when maintained on a high-fat
diet for 6 months followed by a low-fat diet for 1 month, while another subset from the …